Efficacy and safety of SHR8554 on postoperative pain in subjects with moderate to severe acute pain following orthopedic surgery: A multicenter, randomized, double-blind, dose-explored, active-controlled, phase II/III clinical trial

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhao, Yanhua;Lu, Zhisheng;Song, Xuesong;Xie, Haihui;Xiao, Xungang;...

通讯作者：

Su, Diansan;Yu, Weifeng;Gu, XY;Su, DS

作者机构：

[Gu, Xiyao; Yu, Weifeng; Yu, WF; Zhao, Yanhua; Lu, Zhisheng; Su, Diansan] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Anesthesiol, Shanghai, Peoples R China.

[Yu, Weifeng; Zhao, Yanhua; Lu, Zhisheng; Su, Diansan; Gu, Xiyao] Shanghai Jiao Tong Univ, Key Lab Anesthesiol, Minist Educ, Shanghai, Peoples R China.

[Song, Xuesong] First Hosp Jilin Univ, Dept Anesthesiol, Changchun, Peoples R China.

[Xie, Haihui] Southern Med Univ, Dongguan Peoples Hosp, Affiliated Hosp 10, Dept Anesthesiol, Dongguan, Peoples R China.

[Xiao, Xungang] Chenzhou First Peoples Hosp, Dept Orthoped, Chenzhou, Peoples R China.

通讯机构：

[Gu, XY ; Su, DS; Yu, WF] S

[Su, DS ] Z

Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Anesthesiol, Shanghai, Peoples R China.

Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Anesthesiol, Hangzhou, Peoples R China.

语种：

英文

关键词：

Analgesia;Biased μ-opioid receptor agonist;Orthopedic surgery;Patient controlled;Phase II/III clinical trial;Postoperative;SHR8554

期刊：

Pharmacological Research

ISSN：

1043-6618

年：

2025

卷：

212

页码：

107576

DOI：

10.1016/j.phrs.2025.107576

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Biased µ-opioid receptor (MOR) agonists enhance pain relief by selectively activating G protein-coupled receptor signaling and minimizing β-arrestin-2 activation, resulting in fewer side effects. This multicenter Phase II/III trial evaluated the optimal dosage, efficacy, and safety of SHR8554, a biased MOR agonist, for postoperative pain management following orthopedic surgery. In Phase II, 121 patients were divided into four groups to receive varying patient-controlled analgesia (PCA) doses of SHR8554 or morphine. Phase III involved 320 pati...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Efficacy and safety of SHR8554 on postoperative pain in subjects with moderate to severe acute pain following orthopedic surgery: A multicenter, randomized, double-blind, dose-explored, active-controlled, phase II/III clinical trial

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问