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Identification of four novel hub genes as monitoring biomarkers for colorectal cancer

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成果类型:
期刊论文
作者:
Luo, Danqing;Yang, Jing;Liu, Junji*;Yong, Xia;Wang, Zhimin
通讯作者:
Liu, Junji
作者机构:
[Luo, Danqing] Univ South China, Hengyang Med Sch, Affiliated Hosp 2, Spinal Surg, 35 Jiefang Ave, Hengyang 421000, Peoples R China.
[Yang, Jing] Univ South China, Hengyang Med Sch, Affiliated Hosp 2, Anorectal Dept, 35 Jiefang Ave, Hengyang 421000, Peoples R China.
[Liu, Junji] Cent Hosp Shaoyang, Dept Oncol, 36 Qianyuan Lane,Hongqi Rd, Shaoyang, Peoples R China.
[Yong, Xia] Wuhan Inst Technol, Biomed Ctr, Wuhan 430000, Peoples R China.
[Wang, Zhimin] Univ South China, Hengyang Med Sch, Affiliated Hosp 2, Human Resources Dept, 35 Jiefang Ave, Hengyang 421000, Peoples R China.
通讯机构:
[Liu, Junji] C
Cent Hosp Shaoyang, Dept Oncol, 36 Qianyuan Lane,Hongqi Rd, Shaoyang, Peoples R China.
语种:
英文
关键词:
Colorectal Cancer;Potential Pathogenesis;Robust Rank Aggregation;Weighted Gene Co-expression Network Analysis;Hub Gene
期刊:
Hereditas
ISSN:
1601-5223
年:
2022
卷:
159
期:
1
页码:
1-15
基金类别:
This study was supported by the Clinical Medical Technology Innovation Guidance Project of Hunan Province (No. 2018SK51811). All funders had no roles in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
机构署名:
本校为第一机构
摘要:
It must be admitted that the incidence of colorectal cancer (CRC) was on the rise all over the world, but the related treatment had not caught up. Further research on the underlying pathogenesis of CRC was conducive to improving the survival status of current CRC patients. Differentially expressed genes (DEGs) screening were conducted based on “limma” and “RobustRankAggreg” package of R software. Weighted gene co-expression network analysis (WGCNA) was performed in the integrated DEGs that from The Cancer Genome Atlas (TCGA), and all sample...

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