Chlamydia psittaci inclusion membrane protein CPSIT_0842 induces macrophage apoptosis through MAPK/ERK-mediated autophagy

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成果类型：

期刊论文

作者：

Huang, Yanru;Li, Sijia;He, Siqin;Li, Yumeng;He, Qingzhi;...

通讯作者：

Yimou Wu

作者机构：

[Wu, Yimou; Li, Yumeng; Li, Sijia; He, Siqin; Huang, Yanru] Univ South China, Inst Pathogen Biol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Hunan Prov Key Lab Special Preven, Hengyang 421001, Hunan, Peoples R China.

[Li, Yumeng] Univ South China, Affiliated Hosp 1, Dept Clin Lab, Hengyang 421000, Hunan, Peoples R China.

[He, Qingzhi] Guilin Med Univ, Sch Biotechnol, Guilin 541199, Peoples R China.

[Wu, Yimou] Univ South China, Pathogen Biol Inst, Hengyang Med Sch, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Yimou Wu] I

Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang 421001, Hunan, China

语种：

英文

关键词：

Chlamydia psittaci;CPSIT-0842;Incomplete autophagy;Apoptosis;MAPK;ERK pathway

期刊：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ISSN：

1357-2725

年：

2023

卷：

157

页码：

106376

DOI：

10.1016/j.biocel.2023.106376

基金类别：

National Natural Science Foundation of China [31872643, 81671986]; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation [2014-5]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2015-351]; Institute of Pathogenic Biology (University of South China)

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Chlamydia psittaci is a multi-host zoonotic pathogen, which mainly infects poultry and inflicts an appreciable economic burden on the livestock farming industry. C. psittaci inclusion membrane proteins are uniquely posi-tioned at the host-pathogen interface and are important virulence proteins. We have previously confirmed that Incs regulate host cell survival to help Chlamydia sp. evade host-cell-mediated defense mechanisms. However, the role of the Inc, CPSIT_0842, in the regulation of cell death following the establishment of persistent C. psittaci infection remains unknown. This study expl...

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Chlamydia psittaci inclusion membrane protein CPSIT_0842 induces macrophage apoptosis through MAPK/ERK-mediated autophagy

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