Rheb (Ras homolog enriched in brain 1) Deficiency in mature macrophages prevents atherosclerosis by repressing macrophage proliferation, inflammation, and lipid uptake

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成果类型：

期刊论文

作者：

Zhang, Qinghai;Hu, Jie;Wu, Yan;Luo, Hairong;Meng, Wen;...

通讯作者：

Liu, Feng

作者机构：

[Meng, Wen; Wu, Yan; Hu, Jie; Zhou, Zhiguang; Liu, Feng; Luo, Hairong; Xiao, Bo; Zhang, Qinghai] Cent S Univ, Dept Metab & Endocrinol, Metab Syndrome Res Ctr,Xiangya Hosp 2, Key Lab Diabet Immunol,Natl Clin Res Ctr Metab Di, Changsha, Hunan, Peoples R China.

[Zhang, Qinghai] Univ South China, Affiliated Hosp 1, Dept Metab & Endocrinol, Hengyang, Hunan, Peoples R China.

[Xiao, Bo] Southern Univ Sci & Technol, Dept Biol, Shenzhen, Peoples R China.

[Xiao, Xianzhong] Cent S Univ, Xiangya Sch Med, Dept Palhophysiol, Changsha, Hunan, Peoples R China.

[Liu, Feng] UT Hlth San Antonio, Dept Pharmacol, San Antonio, TX USA.

通讯机构：

[Liu, Feng] C

Cent S Univ, Xiangya Hosp 2, 139 Renmin Middle Rd, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

atherosclerosis;foam cells;inflammation;macrophages;mice

期刊：

Arteriosclerosis, Thrombosis, and Vascular Biology

ISSN：

1079-5642

年：

2019

卷：

期：

页码：

1787-1801

DOI：

10.1161/ATVBAHA.119.312870

基金类别：

This work was supported by grants 81730022 to F. Liu and 31400652 to Q. Zhang from the National Natural Science Foundation of China.

机构署名：

本校为其他机构

摘要：

Objective: Macrophage foam cell formation is an important process in atherosclerotic plaque development. The small GTPase Rheb (Ras homolog enriched in brain 1) regulates endocytic trafficking that is critical for foam cell formation. However, it is unclear whether and how macrophage Rheb regulates atherogenesis, which are the focuses of the current study. Approach and Results: Immunofluorescence study confirmed the colocalization of Rheb in F4/80 and Mac-2 (galectin-3)-labeled lesional macrophages. Western blot and fluorescence-activated cell sorting analysis showed that Rheb expression was s...

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Rheb (Ras homolog enriched in brain 1) Deficiency in mature macrophages prevents atherosclerosis by repressing macrophage proliferation, inflammation, and lipid uptake

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