SEC62-dependent ER-phagy contributes to apelin-13/APJ-induced monocyte-vascular endothelial cell adhesion in atherosclerosis pathogenesis

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成果类型：

期刊论文

作者：

Chen, Zhe;Cheng, Jun;Zhou, Qun;Wu, Le-le;Chen, Jia-wei;...

通讯作者：

Li, Lan-fang;Chen, LX;Cao, JG;Xia, XD

作者机构：

[Chen, Jia-wei; Chen, Lin-xi; Yan, Jia-long; Li, Lan-fang; Wu, Le-le; Duan, Xiang-ning; Chen, LX; Chen, Zhe] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Coll Basic Med Sci, Hengyang Med Sch,Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Cheng, Jun] Cent South Univ, Changde Hosp, Peoples Hosp Changde City 1, Xiangya Sch Med, Changde, Peoples R China.

[Zhou, Qun] Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody based Drug & Intellige, Huaihua, Peoples R China.

[Cao, Jian-gang] Univ South China, Affiliated Nanhua Hosp, Clin Pharm Res Inst, Hengyang Med Sch, Hengyang, Peoples R China.

[Xia, Xiao-dan] Guangzhou Med Univ, Affiliated Qingyuan Hosp, Qingyuan Peoples Hosp, Dept Orthoped, Qingyuan, Peoples R China.

通讯机构：

[Li, LF; Chen, LX ; Cao, JG ] U

[Xia, XD ] G

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Coll Basic Med Sci, Hengyang Med Sch,Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

Univ South China, Affiliated Nanhua Hosp, Clin Pharm Res Inst, Hengyang Med Sch, Hengyang, Peoples R China.

Guangzhou Med Univ, Affiliated Qingyuan Hosp, Qingyuan Peoples Hosp, Dept Orthoped, Qingyuan, Peoples R China.

语种：

英文

关键词：

ALDH1L1;Apelin-13/APJ;ER-phagy;SEC62;atherosclerosis;monocyte adhesion

期刊：

中国药理学报

ISSN：

1671-4083

年：

2025

页码：

1-12

DOI：

10.1038/s41401-024-01471-w

基金类别：

National Natural Science Foundation of China [81603108]; Natural Science Foundation of Hunan Province [2023JJ30555]; Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) [2023A1515010295]; Health Research Project of Hunan Provincial Health Commission [202103011014]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

The monocyte adhesion to vascular endothelial cells constitutes a key step in atherosclerosis pathogenesis. We previously found that ROS-autophagy pathway participated in the monocyte-endothelial cell adhesion induced by angiotensin domain type 1 receptor-associated proteins (APJ) and its endogenous ligand apelin-13. In this study, we investigated what specific type of autophagy apelin-13 regulated in this process. By conducting full-scale transcriptomic analysis in apelin-13-treated human umbilical vein endothelial cells (HUVECs), we found tha...

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SEC62-dependent ER-phagy contributes to apelin-13/APJ-induced monocyte-vascular endothelial cell adhesion in atherosclerosis pathogenesis

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