SEC62-dependent ER-phagy contributes to apelin-13/APJ-induced monocyte-vascular endothelial cell adhesion in atherosclerosis pathogenesis

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成果类型：

期刊论文

作者：

Chen, Zhe;Cheng, Jun;Zhou, Qun;Wu, Le-le;Chen, Jia-wei;...

通讯作者：

Li, Lan-fang;Chen, LX;Cao, JG;Xia, XD

作者机构：

[Chen, Jia-wei; Chen, Lin-xi; Yan, Jia-long; Li, Lan-fang; Wu, Le-le; Duan, Xiang-ning; Chen, LX; Chen, Zhe] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Coll Basic Med Sci, Hengyang Med Sch,Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Cheng, Jun] Cent South Univ, Changde Hosp, Peoples Hosp Changde City 1, Xiangya Sch Med, Changde, Peoples R China.

[Zhou, Qun] Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody based Drug & Intellige, Huaihua, Peoples R China.

[Cao, Jian-gang] Univ South China, Affiliated Nanhua Hosp, Clin Pharm Res Inst, Hengyang Med Sch, Hengyang, Peoples R China.

[Xia, Xiao-dan] Guangzhou Med Univ, Affiliated Qingyuan Hosp, Qingyuan Peoples Hosp, Dept Orthoped, Qingyuan, Peoples R China.

通讯机构：

[Li, LF; Chen, LX ; Cao, JG ] U

[Xia, XD ] G

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Coll Basic Med Sci, Hengyang Med Sch,Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

Univ South China, Affiliated Nanhua Hosp, Clin Pharm Res Inst, Hengyang Med Sch, Hengyang, Peoples R China.

Guangzhou Med Univ, Affiliated Qingyuan Hosp, Qingyuan Peoples Hosp, Dept Orthoped, Qingyuan, Peoples R China.

语种：

英文

关键词：

ALDH1L1;Apelin-13/APJ;ER-phagy;SEC62;atherosclerosis;monocyte adhesion

期刊：

中国药理学报(英文)

ISSN：

1671-4083

年：

2025

卷：

期：

页码：

1652-1663

DOI：

10.1038/s41401-024-01471-w

基金类别：

National Natural Science Foundation of China, NSFC, (81603108) National Natural Science Foundation of China, NSFC Natural Science Foundation of Hunan Province, (2023JJ30555) Natural Science Foundation of Hunan Province Natural Science Foundation of Guangdong Province, (2023A1515010295) Natural Science Foundation of Guangdong Province Health Research Project of Hunan Provincial Health Commission, (202103011014)

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

The monocyte adhesion to vascular endothelial cells constitutes a key step in atherosclerosis pathogenesis. We previously found that ROS-autophagy pathway participated in the monocyte-endothelial cell adhesion induced by angiotensin domain type 1 receptor-associated proteins (APJ) and its endogenous ligand apelin-13. In this study, we investigated what specific type of autophagy apelin-13 regulated in this process. By conducting full-scale transcriptomic analysis in apelin-13-treated human umbilical vein endothelial cells (HUVECs), we found tha...

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SEC62-dependent ER-phagy contributes to apelin-13/APJ-induced monocyte-vascular endothelial cell adhesion in atherosclerosis pathogenesis

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