Perivascular adipose tissue dysfunction aggravates adventitial remodeling in obese mini pigs via NLRP3 inflammasome/IL-1 signaling pathway

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成果类型：

期刊论文

作者：

Zhu, Xiao;Zhang, Hong-wen;Chen, Hai-nan;Deng, Xiao-jun;Tu, Yi-xuan;...

通讯作者：

Yin, Kai

作者机构：

[Chen, Hai-nan; Qing, Ji-na; Yin, Kai; Jackson, Ampadu O.; Zhu, Xiao; Tu, Yi-xuan] Univ South China, Med Sch, Res Lab Translat Med, Hengyang 421001, Peoples R China.

[Chen, Hai-nan; Yin, Kai; Zhu, Xiao] Univ South China, Inst Cardiovasc Dis, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Peoples R China.

[Zhang, Hong-wen; Deng, Xiao-jun] Univ South China, Affiliated Hosp, Dept Intervent Med, Hengyang 421001, Peoples R China.

[Wang, Ai-ping] Univ South China, Med Sch, Dept Anat, Hengyang 421001, Peoples R China.

[Patel, Vaibhav] Univ Calgary, Libin Cardiovasc Inst Alberta, Cumming Sch Med, Dept Physiol & Pharmacol, Calgary, AB T2N 1N4, Canada.

通讯机构：

[Yin, Kai] U

Univ South China, Med Sch, Res Lab Translat Med, Hengyang 421001, Peoples R China.

Univ South China, Inst Cardiovasc Dis, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

obesity;perivascular adipose tissue;PVAT dysfunction;adventitia fibroblasts;NLRP3 inflammasome;IL-1;obese mini pigs;preadipocytes

期刊：

中国药理学报

ISSN：

1671-4083

年：

2019

卷：

期：

页码：

46-54

DOI：

10.1038/s41401-018-0068-9

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81100213, 81470569]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018JJ2341]; Innovation Foundation for Postgraduate of Hunan Province [CX2017B550]; Innovation Foundation for Undergraduates of Hunan Province [2017-336]; Scientific Research Foundation for Doctor in University of South China [2015XQD49]; Scientific Research Foundation for the Returned Overseas Chinese Scholars in University of South ChinaScientific Research Foundation for the Returned Overseas Chinese Scholars [2015XQD55]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Perivascular adipose tissue (PVAT), a special type of adipose tissue, closely surrounds vascular adventitia and produces numerous bioactive substances to maintain vascular homeostasis. PVAT dysfunction has a crucial role in regulating vascular remodeling, but the exact mechanisms remain unclear. In this study, we investigated whether and how obesity-induced PVAT dysfunction affected adventitia remodeling in early vascular injury stages. Mini pigs were fed a high sugar and fat diet for 6 months to induce metabolic syndrome and obesity. In the mi...

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Perivascular adipose tissue dysfunction aggravates adventitial remodeling in obese mini pigs via NLRP3 inflammasome/IL-1 signaling pathway

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