期刊论文

Li, Lan-fang;Chen, Lin-xi

英文

中国药理学报

1671-4083

2017

38

12

1589-1600

10.1038/aps.2017.97

This work was supported by grants from the National Natural Science Foundation of China （81503074, 81270420, 81470434, and 81670265）, Hunan Provincial Natural Science Foundation （14JJ3102 2017JJ2227）, China Postdoctoral Science Founda- tion （2014M560647）. We especially thank Bing-bing WANG （Assistant Professor, Perinatal Biology Laboratory, Division of Maternal-Fetal Medicine, Rutgers University-Robert Wood Johnson Medical School, USA） for the English language cor- rection.

本校为第一且通讯机构

Apelin is the endogenous ligand for the G protein-coupled receptor APJ, and plays important roles in the cardiovascular system. Our previous studies showed that apelin-13 promotes the hypertrophy of H9c2 rat cardiomyocytes through the PI3K-autophagy pathway. The aim of this study was to explore what roles ER stress and autophagy played in apelin-13-induced hypertrophy of cardiomyocytes in vitro. Treatment of H9c2 cells with apelin-13 (0.001–2 μmol/L) dose-dependently increased the production of ROS and the expression levels of NADPH oxidase 4...