Hydrogen sulfide inhibits homocysteine-induced endoplasmic reticulum stress and neuronal apoptosis in rat hippocampus via upregulation of the BDNF-TrkB pathway

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成果类型：

期刊论文

作者：

Wei, Hai-jun;Xu, Jin-hua;Li, Man-hong;Tang, Ji-ping;Zou, Wei;...

通讯作者：

Zhang, Ping

作者机构：

[Wei, Hai-jun; Tang, Ji-ping; Tang, Xiao-qing; Li, Man-hong] Univ South China, Coll Med, Inst Neurosci, Hengyang 421001, Peoples R China.

[Xu, Jin-hua] Univ South China, Lab Ctr Biochem & Mol Biol, Hengyang 421001, Peoples R China.

[Tang, Ji-ping; Zou, Wei; Li, Man-hong; Zhang, Ping] Univ South China, Nanhua Affiliated Hosp, Dept Neurol, Hengyang 421001, Peoples R China.

[Wang, Li] Univ South China, Coll Med, Dept Anthropot, Hengyang 421001, Peoples R China.

[Wang, Chun-yan] Univ South China, Coll Med, Dept Pathophysiol, Hengyang 421001, Peoples R China.

通讯机构：

[Zhang, Ping] U

Univ South China, Nanhua Affiliated Hosp, Dept Neurol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

hydrogen sulfide;homocysteine;neurotoxicity;hippocampus;apoptosis;ER stress;BDNF;tyrosine protein kinase B;Alzheimer's disease

关键词(中文)：

同型半胱氨酸;神经细胞凋亡;海马神经元;内质网应激;SD大鼠;硫化氢;诱导;神经细胞死亡

期刊：

中国药理学报

ISSN：

1671-4083

年：

2014

卷：

期：

页码：

707-715

DOI：

10.1038/aps.2013.197

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81202518, 81200985, 81071005]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [11JJ3117, 12JJ9032]; Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education of the People's Republic of ChinaScientific Research Foundation for the Returned Overseas Chinese Scholars [[2011]508]; Construct Program of the Key Discipline in the Hunan province

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Aim:Homocysteine (Hcy) can elicit neuronal cell death, and hyperhomocysteinemia is a strong independent risk factor for Alzheimer's disease. The aim of this study was to examine the effects of hydrogen sulfide (H 2 S) on Hcy-induced endoplasmic reticulum (ER) stress and neuronal apoptosis in rat hippocampus.Methods:Adult male SD rats were intracerebroventricularly (icv) injected with Hcy (0.6 μmol/d) for 7 d. Before Hcy injection, the rats were treated with NaHS (30 or 100 μmol·kg -1 ·d -1, ip) and/or k252a (1 μg/d, icv) for 2 d. The apopt...

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Hydrogen sulfide inhibits homocysteine-induced endoplasmic reticulum stress and neuronal apoptosis in rat hippocampus via upregulation of the BDNF-TrkB pathway

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