Apolipoprotein A-I inhibits LPS-induced atherosclerosis in ApoE~(–/–) mice possibly via activated STAT3-mediated upregulation of tristetraprolin

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成果类型：

期刊论文

作者：

Yin, Kai;Tang, Shi-lin;Yu, Xiao-hua;Tu, Guang-hui;He, Rong-fang;...

通讯作者：

Tu, Jian

作者机构：

[Tang, Chao-ke; Jiang, Zhi-sheng; Yu, Xiao-hua; Yin, Kai; Xie, Di; Li, Jin-feng; Tang, Shi-lin] Univ South China, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res, Hengyang 421001, Peoples R China.

[Gui, Qing-jun; Yin, Kai; Xie, Di] Univ South China, Coll Med, Dept Diagnost, Hengyang 421001, Peoples R China.

[Tang, Shi-lin] Univ South China, Affiliated Hosp 1, Dept Intens Care Unit, Hengyang 421001, Peoples R China.

[Tu, Guang-hui] Nan Xian Peoples Hosp, Dept Pathol, Yiyang 413200, Peoples R China.

[He, Rong-fang] Univ South China, Affiliated Hosp 1, Dept Pathol, Hengyang 421001, Peoples R China.

通讯机构：

[Tu, Jian] U

Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

apolipoprotein A-I;heart;atherosclerosis;inflammation;cytokines;JAK2/STAT3 signaling pathway;tristetraprolin;lipopolysaccharide;ApoE-/-mice;macrophage;apolipoprotein A-I;heart;atherosclerosis;inflammation;cytokines;JAK2/STAT3 signaling pathway;tristetraprolin;lipopolysaccharide;ApoE-/-mice;macrophage

关键词(中文)：

小鼠巨噬细胞;载脂蛋白AI;动脉粥样硬化;载脂蛋白A-I;诱导;激活

期刊：

中国药理学报

ISSN：

1671-4083

年：

2013

卷：

期：

页码：

837-846

DOI：

10.1038/aps.2013.10

基金类别：

The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China （81070220, 81170278, and 81100213） the Heng Yang Joint Funds of Hunan Provincial Natural Sciences Foundation of China （10JJ9019） the Hunan Provincial Natural Sciences Foundation of China （06jj5058） the Science ＆ Technology Department Funds of Heng Yang of Hunan Province （2010kj17 and 2010kj41） and the Hunan Provincial Postgraduate Innovation Fund （CX2010B379）.

机构署名：

本校为第一且通讯机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

摘要：

Aim:To investigate the effects of the major component of high-density lipoprotein apolipoprotein A-I (apoA-I) on the development of atherosclerosis in LPS-challenged ApoE -/- mice and the underlying mechanisms.Methods: Male ApoE-KO mice were daily injected with LPS (25 μg, sc) or PBS for 4 weeks. The LPS-challenged mice were intravenously injected with rAAV-apoA-I-GFP or rAAV-GFP. After the animals were killed, blood, livers and aortas were collected for biochemical and histological analyses. For ex vivo experiments, the abdominal cavity macro...

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Apolipoprotein A-I inhibits LPS-induced atherosclerosis in ApoE~(–/–) mice possibly via activated STAT3-mediated upregulation of tristetraprolin

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