Ibrolipim increases ABCA1/G1 expression by the LXRa signaling pathway in THP-1 macrophagederived foam cells

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成果类型：

期刊论文

作者：

Chen, Si-guo;Xiao, Ji;Liu, Xie-hong;Liu, Mei-mei;Mo, Zhong-cheng;...

通讯作者：

Tang, Chao-ke

作者机构：

[Zhao, Guo-jun; Tang, Chao-ke; Liu, Mei-mei; Tan, Chun-zhi; Liu, Xie-hong; Yin, Wei-dong; Yin, Kai; Jiang, Jin; Mo, Zhong-cheng; Cui, Li-bao; Xiao, Ji; Chen, Si-guo] Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Peoples R China.

[Xiao, Ji] Univ S China, Dept Anesthesiol, Affiliated Hosp 2, Hengyang 421001, Peoples R China.

[Chen, Si-guo] Xiangnan Univ, Dept Physiol, Chenzhou 423000, Peoples R China.

通讯机构：

[Tang, Chao-ke] U

Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

apolipoprotein;atherosclerosis;ATP-binding membrane cassette transporter A-1;ATP-binding membrane cassette transporter G-1;cholesterol;high density lipoprotein;ibrolipim;liver X receptor á;RNA interference

关键词(中文)：

信号转导通路;泡沫细胞;巨噬细胞;氧化型低密度脂蛋白;WESTERN印迹;动脉粥样硬化;高密度脂蛋白

期刊：

中国药理学报

ISSN：

1671-4083

年：

2010

卷：

期：

页码：

1343-1349

DOI：

10.1038/aps.2010.166

基金类别：

Acknowledgements The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China （81070220）, Post-doctor Sciences Foundation of China （2005037157） and Heng Yang Joint Funds of the Hunan Provincial Natural Sciences Foundation of China （10jj9019）, and the National Major Basic Research Program of China （973 Program）（grant No. 2006CB503808）.

机构署名：

本校为第一且通讯机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

摘要：

Aim: To determine the effects and potential mechanisms of ibrolipim on ATP-binding membrane cassette transporter A-1 (ABCA1) and ATP-binding membrane cassette transporter G-1 (ABCG1) expression from human macrophage foam cells, which may play a critical role in atherogenesis. Methods: Human THP-1 cells pre-incubated with ox-LDL served as foam cell models. Specific mRNA was quantified using real-time RT-PCR and protein expression using Western blotting. Cellular cholesterol handling was studied using cholesterol efflux experiments and high perfo...

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Ibrolipim increases ABCA1/G1 expression by the LXRa signaling pathway in THP-1 macrophagederived foam cells

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