期刊论文

Liao, Duan-fang

英文

中国药理学报

1671-4083

2008

29

5

555-563

10.1111/j.1745-7254.2008.00783.x

Project supported by the National Natural Science Foundation of China （No 30470719 and 30770868）, the National Major Basic Research Program of China （973 Program, No 2006CB503808）.

本校为第一且通讯机构

Aim: To investigate the protective effect and the possible mechanism of curcumin on anti-atherosclerosis. Methods: Morphological changes of atherosclerotic lesions taken from apoE knockout (apoE-/-) mice were determined by hematoxylin-eosin staining. Intracellular lipid droplets and lipid levels were assayed by oil red O staining and HPLC. The protein expression of caveolin-1 was quantified by Western blotting. Translocation and the expression of sterol response element-binding protein-1 (SREBP-1) were indirectly detected by an immunofluorescen...

目的: 在 anti-atherosclerosis.Methods 上调查保护的效果和杂种狗枯茗的可能的机制: 从 apoE 大美人拿的动脉粥样硬化患者损害的词法变化(apoE~(-/-))mice 被染色的 hematoxylin 曙红决定。细胞内部的类脂化合物微滴和类脂化合物层次是由油红Ｏ染色的 assayed ， caveolin-1 的 HPLC.The 蛋白质表示被西方的 blotting.Translocation 和甾醇反应元素绑定 protein-1 ( SREBP-1 )的表示确定被免疫荧光 analysis.Results 间接地检测: 20 mg ·k g~的管理( -1)·d~(-1)curcumin 到apoE~(为 4 个月的 -/-)mice 导致了动脉粥样硬化患者损害的50%减小并且作为与模型组相比在 caveolin-1 表示水平产出5...