[Chen, WZ] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China.
Hengyang Med Coll, Dept Pharmacol, Hengyang 421001, Peoples R China.
通讯机构：
[Chen, WZ] C
Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China.
语种：
英文
关键词：
Eposprostenol;Flavones;Ginggolides;Ginkgo biloba;Lysophosphatidylcholines;Malondialdehyde;Thoracic aorta;Vascular endothelium;Vitamin E
关键词(中文)：
银杏;黄酮;银杏内酯;溶血磷酯酰;胆碱类;血管内皮;依前列醇;丙二醛;胸主动脉;维生素E
期刊：
中国药理学报
ISSN：
1671-4083
年：
1998
卷：
19
期：
4
页码：
359-363
机构署名：
本校为其他机构
院系归属：
医学院
药学与生物科学学院
摘要：
AIM: To study the protective effects of Ginkgo biloba extract (GbE) against endothelial cell damage induced by lysophosphatidylcholine (LPC). METHODS: The vasorelaxation response to acetylcholine (ACh) were investigated in the isolated rabbit thoracic aorta. Lipid peroxidation products were determined by measuring thiobarbituric acid reactive substance. RESULTS: GbE attenuated the inhibition of vasorelaxation response to ACh and prevented the LPC-induced increase of malondialdehyde (MDA) content both in thoracic aortae. GbE prevented the leakage of LDH and the increase of MDA content in cultur...
