期刊论文

中文

中华高血压杂志

1673-7245

2001

9

4

322-325

10.16439/j.cnki.1673-7245.2001.04.020

本校为其他机构

目的探讨SHR心脏肥厚进展阶段心肌细胞凋亡、心肌纤维化及左室重构特点及其相互关系.方法分别采用末端脱氧核糖核苷酸转移酶介导dUTP缺口末端标记(TUNEL)、放射免疫测定及病理检查方法对16周龄、24周龄、32周龄SHR心肌细胞凋亡指数(APOI)、心肌胶原容积分数(CVF)和心肌血管周围胶原面积(PVCA)、血浆和组织血管紧张素Ⅱ检测,并以同龄Wister大鼠作对照.结果与同龄正常血压Wistar大鼠比较,SHR各周龄组收缩压明显增高、心脏肥厚指标心脏重量(HW)、左室重量(LVW)、左室重量指数(LVW/BW)均显著增加;各周龄组SHR心肌细胞APOI显著增加,各周龄组间无显著性差异;各周龄组SHR大鼠血浆、心肌组织AngⅡ明显增...

Objective To investigate dynamic changes of cardiomyocyte apoptosis and myocardial fibrosis during the development of cardiac hypertrophy in the spontaneously hypertensive rats(SHR). Methods We studied the hearts specimens from 16,24 and 32 weeks old SHRs and age matched Wister Kyoto rats(WKY). Cardiomyocyte apoptosis was identified by in situ TDT mediated dUTP nick end labeling(TUNEL). The collagen volume fraction (CVF) and perivascular circumferential area (PVCA) were measured by pathological examination. The plasma and myocardium angiotensin...