circIQCH sponges miR-145 to promote breast cancer progression by upregulating DNMT3A expression

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Yuehua;Jiang, Baohong;He, Zhengxi;Zhu, Hongbo;He, Rongfang;...

通讯作者：

Xie, Liming;He, Xiusheng

作者机构：

[Zhu, Hongbo; Li, Yuehua; Xie, Liming; Wu, Xiaoping] Univ South China, Affiliated Hosp 1, Dept Med Oncol, Hengyang 421001, Hunan, Peoples R China.

[Li, Yuehua; He, Xiusheng] Univ South China, Hengyang Med Coll, Canc Res Inst, Key Lab Canc Cellular & Mol Pathol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Jiang, Baohong] Univ South China, Affiliated Hosp 1, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

[He, Zhengxi] Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha 410008, Hunan, Peoples R China.

[He, Rongfang] Univ South China, Affiliated Hosp 1, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Xie, Liming; He, Xiusheng] U

Univ South China, Affiliated Hosp 1, Dept Med Oncol, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Coll, Canc Res Inst, Key Lab Canc Cellular & Mol Pathol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

DNMT3A;breast cancer;circIQCH;circular RNAs;competitive endogenous RNAs

期刊：

AGING-US

ISSN：

1945-4589

年：

2020

卷：

期：

页码：

15532-15545

DOI：

10.18632/aging.103746

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81902707]; Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [2018JJ6092, 2019JJ50537]; Health and Family Planning Commission of Hunan Province [20190169, 20190229, 20190107]; Science and Technology Project of Hengyang [S2018F9031021272]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

As a unique type of RNA, circular RNAs (circRNAs) are important regulators of multiple biological processes in the progression of cancer. However, the potential role of most circRNAs in breast cancer lung metastasis is still unknown. In this study, we characterized and further investigated circIQCH (hsa_circ_0104345) by analyzing the circRNA microarray profiling in our previous study. circIQCH was upregulated in breast cancer tissues, especially in the metastatic sites. CCK-8, transwell, wound-healing and mouse xenograft assays were carried out to investigate the functions of circIQCH. Knockdo...

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circIQCH sponges miR-145 to promote breast cancer progression by upregulating DNMT3A expression

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