期刊论文

中文

中国新药与临床杂志

1007-7669

1999

18

1

20-22

10.3969/j.issn.1007-7669.1999.01.005

本校为第一机构

目的:研究L-精氨酸片对冠心病心绞痛的疗效及其安全性.方法:对68例冠心病心绞痛病人分为2组,L-精氨酸组38例(男性24例,女性14例,年龄60a±s 9a)和安慰剂组30例(男性18例,女性12例 ,年龄62a±9a), 以双盲对照法给L-精氨酸或安慰剂片(淀粉)各4片(0. 25 g/片),po, tid, 共4 wk.结果:L-精氨酸组临床与心电图总有效率依次为95%和74%;安慰剂组依次为63%和40%,2组组间比较,依次为P＜0.01和P＜0.05.L-精氨酸能降低血压、降低心肌氧耗及降低血脂 (P＜0.01或＜0.05).未见明显不良反应.结论 :L-精氨酸片是安全有效的治疗心绞痛的药物.

AIM: To study the clinical efficacy and safety with L_arginine in the treatment of angina pectoris. METHODS: The double_blind method was used, 4 tablets (0.25 g/tab) po, tid were used both in L_arginine group (38 patients, M 24, F 14, age 60 a±s 9 a) and in starch placebo group (30 patients, M 18, F 12, age 62 a±9 a) for 4 wk. RESULTS: The total clinical effective rate was 95%, ECG effective rate was 74% for L_arginine group; 63% and 40% respectively for placebo group. There were great differences between two groups (P< 0.01). L_arginine redu...