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Total Flavonoids from Camellia oleifera Alleviated Mycoplasma pneumoniae-Induced Lung Injury via Inhibition of the TLR2-Mediated NF-κB and MAPK Pathways

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成果类型:
期刊论文
作者:
Ding, Nan;Lei, Aihua;Shi, Zhisheng;Xiang, Lin;Wei, Bo;...
通讯作者:
Wu, YM;Wei, B
作者机构:
[Wu, Yimou; Shi, Zhisheng; Lei, Aihua; Xiang, Lin; Wu, YM; Ding, Nan] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hunan Prov Key Lab Special Pathogens Prevent & Con, Inst Pathogen Biol,Hengyang Med Coll, Hengyang 421001, Peoples R China.
[Wei, Bo] Univ South China, Hengyang Med Coll, Res Lab Translat Med, Hengyang 421001, Peoples R China.
通讯机构:
[Wu, YM ; Wei, B ] U
Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hunan Prov Key Lab Special Pathogens Prevent & Con, Inst Pathogen Biol,Hengyang Med Coll, Hengyang 421001, Peoples R China.
Univ South China, Hengyang Med Coll, Res Lab Translat Med, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
flavonoid;immunoglobulin enhancer binding protein;TLR2 protein, human;toll like receptor 2;animal;Camellia;child;genetics;human;lung injury;metabolism;mouse;Mycoplasma pneumoniae;pneumonia;Animals;Camellia;Child;Flavonoids;Humans;Lung Injury;Mice;Mycoplasma pneumoniae;NF-kappa B;Pneumonia;Toll-Like Receptor 2
期刊:
Molecules
ISSN:
1420-3049
年:
2023
卷:
28
期:
20
页码:
7077-
基金类别:
This work was supported by the National Natural Science Foundation of China (grant Nos. 82101869, 81671986, and 31872643), the Natural Science Foundation for Young Scientists of Hunan Province (grant Nos. 2021JJ40471 and 2021JJ40478), the Scientific research project of Hunan Education Department (grant Nos. 21B0404 and 20B506), and the Hunan University students Innovation and Entrepreneurship training program (grant Nos. S202110555319, S202110555105, 2022X10555107, and 2022X10555113). We would like to give our sincere appreciation for the help from the Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation under Grant No. 2014-5, and the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (2015-351).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Mycoplasma pneumoniae (M. pneumoniae) is an atypical bacterial pathogen responsible for community-acquired pneumonia primarily among school-aged children and young adults. Camellia oleifera (C. oleifera) has been used as a medicinal and edible plant in China for centuries, the constituents from which possessed various bioactivities. Notably, flavonoids existing in residues of C. oleifera defatted seeds exhibited significant anti-inflammatory activities. In the present study, we investigated the impact of total flavonoids from C. oleifera (TFCO)...

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