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Eicosapentaenoic acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic AMP/protein kinase A signaling pathway in THP-1 macrophage-derived foam cells

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成果类型:
期刊论文
作者:
Hu, Yan-Wei;Ma, Xin;Li, Xiao-Xu;Liu, Xie-Hong;Xiao, Ji;...
通讯作者:
Tang, C.-K.
作者机构:
[Hu, Yan-Wei] Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center, University of South China, Hengyang, Hunan 421001 China
Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China
Research Unit, Health Research Division, Saskatchewan Cancer Agency, Department of Oncology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 4H4, Canada
Institute of Pharmacy and Pharmacology, Life Science Research Center, University of South China, Hengyang, Hunan 421001, China
通讯机构:
Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center, China
语种:
英文
关键词:
ABCA1;Atherosclerosis;EPA;Reverse cholesterol transport;cAMP/PKA
期刊:
Ateroskleroz
ISSN:
2078-256X
年:
2009
卷:
204
期:
2
页码:
e35-e43
机构署名:
本校为第一机构
院系归属:
国防科学技术学院
医学院
药学与生物科学学院
摘要:
ABCA1 is a key mediator of cholesterol efflux to apoA-I in cholesterol loaded macrophages, a first step of RCT in vivo. Unsaturated fatty acids can inhibit cholesterol efflux from macrophages by increasing degradation of ABCA1. However, the detailed mechanisms of ABCA1 regulation by unsaturated fatty acids are not fully understood. In the present study, we investigated the effects of EPA on ABCA1 expression and ABCA1-dependent cholesterol efflux and examined the role of cAMP/PKA pathway on the regulation of ABCA1 by EPA in THP-1 macrophage-derived foam cells. Results showed that EPA significan...

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