Genipin protects rats against lipopolysaccharide-induced acute lung injury by reinforcing autophagy

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Zhijie;Wang, Xue;Ma, Chengzhou;Li, Zhiwang;Chen, Huayong;...

通讯作者：

Zhang, Zhiming;Li, Tao

作者机构：

[Wang, Xue; Zhang, Zhijie; Chen, Huayong] Yidu Cent Hosp Weifang, Dept Anesthesiol, Weifang, Shandong, Peoples R China.

[Ma, Chengzhou] Dongcheng St Hosp Linqu, Dept Anesthesiol, Weifang, Shandong, Peoples R China.

[Zhang, Zhiming; Li, Zhiwang] Univ South China, Inst Translat Med, Peoples Hosp Chenzhou 1, Dept Anesthesiol, 102 Luojiajing, Chenzhou 423000, Peoples R China.

[Li, Tao] Univ South China, Inst Translat Med, Peoples Hosp Chenzhou 1, Dept Crit Care Med, 102 Luojiajing, Chenzhou 423000, Peoples R China.

通讯机构：

[Zhang, Zhiming; Li, Tao] U

Univ South China, Inst Translat Med, Peoples Hosp Chenzhou 1, Dept Anesthesiol, 102 Luojiajing, Chenzhou 423000, Peoples R China.

Univ South China, Inst Translat Med, Peoples Hosp Chenzhou 1, Dept Crit Care Med, 102 Luojiajing, Chenzhou 423000, Peoples R China.

语种：

英文

关键词：

Acute lung injury;Apoptosis;Autophagy;Genipin;Inflammation;Mitochondria

期刊：

International Immunopharmacology

ISSN：

1567-5769

年：

2019

卷：

期：

页码：

21-30

DOI：

10.1016/j.intimp.2019.03.052

基金类别：

Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018JJ6004, 2018JJ3015]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500066, 81601708]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Although the protective effects of genipin against acute lung injury (ALI) have been described previously, the associated mechanism remains unclear. We have previously reported that genipin exerts its pharmacological effects by regulating autophagy. Here, we hypothesized that the up-regulation of autophagy may contribute to the protective effects exhibited by genipin against ALI. In the present study, ALI was induced by intratracheal LPS administration in rats. Genipin treatment significantly reduced LPS-induced lung injury as evidenced by impr...

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Genipin protects rats against lipopolysaccharide-induced acute lung injury by reinforcing autophagy

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