期刊论文

中文

中国职业医学

2095-2619

2001

28

4

9-11

10.3969/j.issn.1000-6486.2001.04.004

湖南省教委科研基金资助项目（编号 971 1 6）；

本校为第一机构

目的通过观察肝组织脂质过氧化和元素含量的变化,探讨烹调油烟致肝损伤的毒作用机理.方法利用SD大鼠动式吸入烹调油烟浓度(43±4)mg/m3为染毒组,吸入加热空气(24～28℃)为阴性对照组,分别于染毒第20、40、60天收集肝脏标本测定肝组织SOD活性和MDA及Zn、Cu、Fe、Ca含量.结果烹调油烟可使肝组织MDA含量增高,SOD活性下降;钙铁值随染毒时间延长增多,锌降低.结论烹调油烟致肝脂质过氧化和元素钙铁超载锌降低,可能存在对肝损伤的协同作用.

Objective To observe the liver tissue lesion and its mechanism in SD rats inhaled cooking oil fumes (COF). Methods After inhalation of COF [(43±4) mg/m 3, 30 min/d, 20, 40, 60 days], the activity of superoxide dismutase (SOD) and the content of the malondialdehyde (MDA) and zinc, copper, iron and calcium in liver tissues in rats were observed. Results COF inhalation group appeared to have higher MDA content and lower SOD acitivities than that of the control group. The contents of iron and calcium in liver increased gradually as the hepatic dam...