International Journal of Clinical and Experimental Medicine
ISSN：
1940-5901
年：
2015
卷：
8
期：
11
页码：
20368-20379
基金类别：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81102230, 31470277]; Innovation Platform of Open Fund Project for Universities in Hunan Province [13K081]; High Medical Talent Project "225" Program in Hunan Province [2013-13]; Construct Program of the Key Discipline in Hunan Province [2011-76]; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control [20145]; Hunan Province Cooperative innovation Center for Molecular Target New Drug Study [2014-405]
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
The pathogenesis of Chlamydia-induced inflammation is poorly understood. pORF5 is the only secreted protein encoded by Chlamydial plasmid. This study aims to investigate the effects of pORF5 on the production of interleukin-1 beta (IL-1 beta) and interleukin-18 (IL-18) and the underlying mechanisms of these effects. THP-1 (a human acute monocytic leukemia cell line) cells were stimulated by pORF5 with or without pretreatment with Natch domain, Leucine-rich repeat and PYD-containing protein 3 (NALP3) siRNA, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) si...
