期刊论文

Yuan, Z.-H.

中文

中国生物化学与分子生物学报

1007-7626

2022

38

6

736-741

10.13865/j.cnki.cjbmb.2022.01.1279

Supported by National Natural Science Foundation of China (No. 81973326); Hunan Provincial Department of Education (No. 17C1476) and Chenzhou Science and Technology Bureau (No. CZKJ2016028)

本校为第一机构

脂滴(lipid droplets)是细胞内脂质贮存和调节细胞脂质稳态的重要细胞器,其表面具有多种脂滴相关蛋白质。长链酰基辅酶A合成酶家族的成员脂酰辅酶A长链合成酶3(acyl CoA long chain synthetase 3,ACSL3)即脂滴相关蛋白质的一种,也是生物合成过程中必需的酶之一。ACSL3广泛分布于大多数细胞中的脂滴表面,其在脂滴的合成、自噬的调节和细胞铁死亡等多种病理生理过程中发挥着不同的作用。此外,多项研究表明,ACSL3还广泛参与到多种疾病的发生发展,包括动脉粥样硬化、非酒精性脂肪肝病、糖尿病和肿瘤等。当前,国内对ACSL3的研究相对集中于ACSL3与动物育种和生长的关系,而对ACSL3在脂质代谢中的作用机...

Lipid droplets are important organelles that have the function of storing intracellular lipid and regulation of cell lipid homeostasis. A variety of lipid droplet-related proteins exists on the surface of lipid droplets. The acyl CoA long chain synthetase 3 (ACSL3) of the long chain acyl-CoA synthetase family is a kind of lipid droplet-related protein and an essential enzyme in the process of biosynthesis. ACSL3, which plays different roles in a variety of pathophysiological processes such as the synthesis of lipid droplets, the regulation of a...