期刊论文

Tian, S.-W.

中文

中国生物化学与分子生物学报

1007-7626

2022

38

4

418-423

10.13865/j.cnki.cjbmb.2021.07.1123

Supported by Natural Science Foundation of Hunan Province‚ China (No. 2019JJ40237); Guangxi Natural Science Foundation Program (No. 2019JJA140715) and Independent Program of Guangxi Key Laboratory of Brain and Cognitive Neuroscience (No.GKLBCN-20190102)

本校为第一机构

一直以来,乳酸在脑中被视作代谢废物,对其功能认识严重滞后。近年来,越来越多的证据表明,乳酸在多种生理与病理过程中扮演重要角色。在神经细胞中,星形胶质细胞是产生和释放乳酸的主要细胞源,该细胞通过有氧糖酵解过程生成乳酸,随后经跨膜通道释放至胞外进入神经元为其供能。在中枢神经系统中,乳酸对稳态调节发挥着十分重要的作用。乳酸主要通过两种途径,即代谢途径(作为能量底物)与信号途径(作为信号分子)调控神经元的功能活动,广泛参与神经元能量代谢、兴奋性、可塑性、学习记忆及神经系统发育等生理过程调节,亦参与抑郁行为、阿尔兹海默病(AD)和脑损伤等病理过程的调节。在脑组织中,存在着乳...

Lactate has always been regarded as a metabolic waste in the brain‚ and the understanding of its functions have been seriously lagging behind. In recent years‚ more and more experimental evidence has shown that lactate plays an important role in a variety of physiological and pathological processes. Among nerve cells‚ astrocytes are the main source of cells for the production and release of lactate. The cells produce lactate through aerobic glycolysis‚ which is then released to the outside of the cells via transmembrane channels and enters ...