期刊论文

The Role of SPHK-S1P Axis in Angiogenesis-related Diseases

Yi, G.-H.

中文

中国生物化学与分子生物学报

1007-7626

2021

37

05

580-587

10.13865/j.cnki.cjbmb.2021.02.1587

Supported by Natural Science Foundation of China (No.81770490) and Natural Science Foundation of Hunan Province (No.2020JJ4535)

本校为第一机构

血管生成是指在原有血管的基础上形成新血管的过程。病理性血管生成是癌症、心血管类疾病和视网膜病变等一系列疾病的标志。1-磷酸鞘氨醇（sphingosine-1-phosphate, S1P）是一种信号脂质,由鞘氨醇激酶（sphingosine kinases, SPHK）合成,通过5种G蛋白偶联受体（sphingosine-1-phosphate receptors, S1PR1-5）发挥其不同的生物学和病理生理作用,并通过激活受体启动各种信号级联反应,影响细胞命运、血管张力、内皮功能和完整性以及淋巴细胞的运输等。其产生和信号的失衡与内皮功能障碍和异常血管生成等病理过程密切相关。越来越多的证据表明,SPHK-S1P轴在血管生成中发挥重要作用,尤其在癌症的发生...

Angiogenesis refers to the process of forming new blood vessels based on original blood vessels. Pathological angiogenesis is a sign of a series of diseases such as cancer, cardiovascular diseases, and retinopathy. Sphingosine 1-phosphate (S1P) is a signaling lipid synthesized by sphingosine kinase (SPHK) that exerts its diverse biological and pathophysiological roles through five G protein-coupled receptors (S1PR1-5) and initiates various signaling cascades by activating receptors that affect cell fate, vascular tension, endothelial function a...