期刊论文

Zhang, Kai-Li;Liu, Jia

英文

Frontiers in Endocrinology

1664-2392

2019

10

467874

10.3389/fendo.2019.00734

This work was supported by the grants from the National Natural Science Foundation of China (No. 81272786 and 81450016), the Program Fund for Liaoning Provincial Department of Education Key Laboratory (LF2017002), the Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, and the special grant to the creative research team from South China University of Technology.

本校为通讯机构

Background: Cellular retinoic acid binding protein 2 (CRABP2) mediates retinoic acid/RA anti-cancer pathways. Resveratrol effectively reverses RA tolerance and upregulates CRABP2 expression of anaplastic thyroid cancer cell line THJ-11T. As DNA methylation is responsible for CRABP2 silencing, the CRABP2 methylation status of THJ-11T cells and the demethylating effect of resveratrol on this gene are elucidated. Materials and methods: The statuses of CRABP2 expression and methylation and the levels of DNA methyltransferases (DNMTs) DNMT1, DNMT3A,...