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Higher fibrinogen and neutrophil-to-lymphocyte ratio are associated with the early poor response to intravenous thrombolysis in acute ischemic stroke

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成果类型:
期刊论文
作者:
Deng, Mingzhu;Song, Kangping;Tong, Yangping;Chen, Sufen;Xu, Wei;...
通讯作者:
Wang, Zhen;Li, FY
作者机构:
[Deng, Mingzhu] Second Peoples Hosp Hunan Prov, Brain Hosp Hunan Prov, Dept Neurol, Changsha, Hunan, Peoples R China.
[Song, Kangping; Li, Fangyi; Wang, Zhen; Xiao, Hui; He, Guohua; Chen, Sufen; Tong, Yangping; Xu, Wei; Wan, Changmin; Hu, Jue; Li, FY] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Neurol, Changsha, Hunan, Peoples R China.
通讯机构:
[Wang, Z; Li, FY ] U
Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Neurol, Changsha, Hunan, Peoples R China.
语种:
英文
关键词:
Acute ischemic stroke;intravenous thrombolysis;Fibrinogen;Neutrophil-to-lymphocyte ratio;response
期刊:
FRONTIERS IN NEUROLOGY
ISSN:
1664-2295
年:
2024
卷:
15
页码:
1291950
基金类别:
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the Medical Clinical Research 4310 Project of University of South China (No. KJZX2021078).
机构署名:
本校为通讯机构
院系归属:
医学院
摘要:
Background: Inflammation and platelet activation play pivotal roles in acute ischemic stroke (AIS) pathogenesis. Early response to thrombolysis is a vital indicator for the long-term prognosis of AIS. However, the correlation between fibrinogen or the neutrophil-to-lymphocyte ratio (NLR) and the early response to intravenous thrombolysis in patients with AIS remains unclear. Methods: AIS patients undergoing intravenous thrombolysis were enrolled between January 2018 and May 2023. Blood cell counts were sampled before thrombolysis. A good response was defined as a National Institutes of Health ...

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