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The Mechanism of Downregulation of Twist1 Inhibiting Trophoblast Invasion and Aggravating the Development of Preeclampsia

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成果类型:
期刊论文
作者:
Yang, Shuangjian;Tong, Wenjuan;Li, Yi
通讯作者:
Li, Y.
作者机构:
[Tong, Wenjuan; Yang, Shuangjian; Li, Yi] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Gynecol & Obstet, Hengyang, Peoples R China.
通讯机构:
[Li, Y.] T
The First Affiliated Hospital, Department of Gynecology and Obstetrics, Hengyang Medical School, University of South China, Hengyang, China
语种:
英文
关键词:
invasion ability;placental trophoblast cells;preeclampsia;transcription factor Twist1;urine protein
期刊:
FRONTIERS IN SURGERY
ISSN:
2296-875X
年:
2022
卷:
9
页码:
862716
基金类别:
This study was supported by the 2021 Hunan Provincial Health Commission Scientific Research Project (202105020156).
机构署名:
本校为第一机构
摘要:
To study the expression of under expressed transcription factor Twist1 in preeclampsia (PE) and its effect on the invasion of placental trophoblast cells and to explore its related mechanism on the development of PE by establishing a pregnant rat model. Methods: the villi were collected from the induced abortion in the first trimester (6–8 weeks), the normal placenta (18–20 weeks) induced by the second trimester, the term placenta tissue of normal pregnancy (37–40 weeks), and the placental tissue of patients with PE, to detect the expression...

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