MicroRNA-22 regulates the proliferation, drug sensitivity and metastasis of human glioma cells by targeting SNAIL1

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成果类型：

期刊论文

作者：

Zhang, Yunqiang*;Tu, Lijun;Zhou, Xiuhong;Li, Bin

通讯作者：

Zhang, Yunqiang

作者机构：

[Li, Bin; Zhang, Yunqiang] Chenzhou Peoples Hosp, Dept Neurosurg, Chenzhou 423000, Hunan, Peoples R China.

[Tu, Lijun] Chenzhou Peoples Hosp, Electrocardiog Room, Chenzhou 423000, Hunan, Peoples R China.

[Zhou, Xiuhong] Univ South China, Dept Pathophysiol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zhang, Yunqiang] C

Chenzhou Peoples Hosp, Dept Neurosurg, Chenzhou 423000, Hunan, Peoples R China.

语种：

英文

关键词：

cisplatin;cyclin B1;microRNA 22;protein;snail1 protein;unclassified drug;microRNA;MIRN22 microRNA, human;SNAI1 protein, human;transcription factor Snail;Article;cell invasion;cell migration;cell proliferation;cell viability;controlled study;drug sensitivity;G2 phase cell cycle checkpoint;gene function;gene overexpression;gene targeting;genetic transfection;glioma;human;human cell;metastasis;U-87MG ATCC cell line;biosynthesis;brain tumor;cell proliferation;genetics;glioma;M phase cell cycle checkpoint;metabolism;metastasis;pathology;physiology;tumor cell line;Brain Neoplasms;Cell Line, Tumor;Cell Proliferation;G2 Phase Cell Cycle Checkpoints;Glioma;Humans;M Phase Cell Cycle Checkpoints;MicroRNAs;Neoplasm Metastasis;Snail Family Transcription Factors;Transfection

期刊：

Journal of BUON

ISSN：

1107-0625

年：

2020

卷：

期：

页码：

491-496

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Purpose: Gliomas are aggressive brain tumors accounting for significant mortality across the globe. Biomarkers for early detection and therapeutic targets for efficient treatment are lacking for glioma. This study was undertaken to investigate the role and therapeutic implications of miR-22 in glioma. Methods: U-87 glioma cell line was used in this study. qRT-PCR was employed for expression analysis. MTT assay was used for determination of cell viability. Lipofectamine 2000 was used for transfection. Flow cytometry was used for cell analysis. W...

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MicroRNA-22 regulates the proliferation, drug sensitivity and metastasis of human glioma cells by targeting SNAIL1

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