Nox1/4 dual inhibitor GKT137831 attenuates hypertensive cardiac remodelling associating with the inhibition of ADAM17-dependent proinflammatory cytokines-induced signalling pathways in the rats with abdominal artery constriction

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期刊论文

作者：

Zeng, Si-yu*;Yang, Li;Yan, Qiu-jiang;Gao, Ling;Lu, Hui-qin*;...

通讯作者：

Zeng, Si-yu;Lu, Hui-qin;Yan, Peng-ke

作者机构：

[Zeng, Si-yu; Lu, Hui-qin] Guangdong Second Prov Gen Hosp, Inst Drug Clin Trial, Guangzhou, Guangdong, Peoples R China.

[Yang, Li] Univ South China, Inst Pharm & Pharmacol, Lab Vasc Biol, Hengyang, Peoples R China.

[Yan, Qiu-jiang] Guangzhou Med Univ, Affiliated Hosp 3, Dept Cardiac & Thorac Surg, Guangzhou, Guangdong, Peoples R China.

[Gao, Ling] Guangdong Second Prov Gen Hosp, Dept Pharm, Guangzhou, Guangdong, Peoples R China.

[Yan, Peng-ke] Guangzhou Med Univ, Affiliated Hosp 3, Dept Pharm, Guangzhou, Guangdong, Peoples R China.

通讯机构：

[Zeng, SY; Lu, HQ; Yan, Peng-ke] G

Guangdong Second Prov Gen Hosp, Inst Drug Clin Trial, Guangzhou, Guangdong, Peoples R China.

Guangzhou Med Univ, Affiliated Hosp 3, Dept Pharm, Guangzhou, Guangdong, Peoples R China.

语种：

英文

关键词：

GKT137831;Hypertensive cardiac remodelling;Proinflammatory cytokines;A disintegrin and metalloprotease 17

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2019

卷：

109

页码：

1907-1914

DOI：

10.1016/j.biopha.2018.11.077

基金类别：

Natural Science Foundation of Guangdong Province, ChinaNational Natural Science Foundation of Guangdong Province [2015A030310076]; Science and Technology Planning Project of Guangdong Province, China [2016A020226005]; Science Foundation of Guangdong Second Provincial General Hospital [YZ2015-008]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

NADPH oxidases (Noxs) 1/4 dual inhibitor GKT137831 prevents hypertensive cardiac remodelling in angiotensin II-infused transgenic mice with cardiomyocyte-specific human Nox4 (c-hNo x 4 Tg); however, further research is still required to determine the beneficial role of GKT137831 in hypertensive cardiac remodelling in other types of hypertensive models because this hypertensive model is insufficient to mimic the complicated pathological mechanisms of hypertension. A disintegrin and metalloprotease 17 (ADAM17) promotes the shedding of tumour necrosis factor alpha (TNF-alpha), TNF-alpha receptor,...

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Nox1/4 dual inhibitor GKT137831 attenuates hypertensive cardiac remodelling associating with the inhibition of ADAM17-dependent proinflammatory cytokines-induced signalling pathways in the rats with abdominal artery constriction

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