Localization and characterization of a putative cysteine desulfurase in Chlamydia psittaci.

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成果类型：

期刊论文

作者：

Wen, Yating;Chen, Yanbo;Li, Li;Xu, Man;Tan, Yuan;...

通讯作者：

Wu, Yimou

作者机构：

[Wu, Yimou; Li, Yumeng; Kuang, Xingxing; Tan, Yuan; Wen, Yating; Wang, Chuan; Xu, Man; Chen, Qian] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pathogen Biol,Med Coll, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang, Peoples R China.

[Chen, Yanbo] Jiangmen Wuyi Tradit Chinese Med Hosp, Dept Clin Lab, Jiangmen, Peoples R China.

[Li, Li] Hunan Prov Ctr Dis Control & Prevent, Toxicol Lab, Changsha, Hunan, Peoples R China.

[Wu, Yimou] Univ South China, Med Coll, Inst Pathogen Biol, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Med Coll, Inst Pathogen Biol, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

cellular localization;Chlamydia psittaci;cysteine desulfurase;mitochondria-mediated pathway;T3SS

期刊：

JOURNAL OF CELLULAR BIOCHEMISTRY

ISSN：

0730-2312

年：

2019

卷：

120

期：

页码：

4409-4422

DOI：

10.1002/jcb.27727

基金类别：

We thank Jian Song of Wuhan University, College of Life Sciences, for the CLSM. We thank Ranhui Li of University of South China, Medical College, and Guobao Liu of Shenzhen University, College of Life Sciences and Oceanography, for CD. Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Grant/Award Number: 2015‐351; the Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation, Grant/Award Number: 2014‐5; National Natural Science Foundation of China, Grant/Award Numbers: 81671986, 31600150

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Chlamydia psittaci is an obligate intracellular pathogen with a biphasic developmental life cycle. It is auxotrophic for a variety of essential metabolites and obtains amino acids from eukaryotic host cells. Chlamydia can develop inside host cells within chlamydial inclusions. A pathway secreting proteins from inclusions into the host cellular cytoplasm is the type III secretion system (T3SS). The T3SS is universal among several Gram-negative bacteria. Here, we show that CPSIT_0959 of C. psittaci is expressed midcycle and secreted into the infe...

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Localization and characterization of a putative cysteine desulfurase in Chlamydia psittaci.

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