[Yang, Xiaoyan; Liu, Daquan; Cao, Pu; Xie, Zhizhong; Lei, Xiaoyong; Ye, Simin; Yang, Wei] Univ South China, Hengyang Med Coll, Sch Pharm, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
[Lei, Xiaoyong] Univ South China, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang, Hunan, Peoples R China.
通讯机构：
[Xiaoyong Lei] S
School of Pharmacy, Hengyang Medical College, University of South China, Hengyang, Hunan, China<&wdkj&>The Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang, Hunan, China
Hengyang City Science and Technology Planning Project [202150063473]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2014-405]; Scientific Research Project of Hunan Provincial Education Department [21B0438]; Scientific Research Project of Hunan Provincial Health Commission [202202044140]
机构署名：
本校为第一机构
院系归属：
药学与生物科学学院
摘要：
Cancer is the second leading cause of death among human diseases. Immunotherapy has opened a new chapter in cancer treatment. However, the emergence of immune escape mechanisms severely limited its application. The high expression of PD-L1 on tumour cells is an important means for cancer cells to achieve immune escape via binding to PD-1 on immune cells. Recent studies have shown that PD-L1 expression in most cancer cells is over-glycosylated. Glycosylation is a fundamental and extensive post-translational modification of eukaryotic membrane-binding proteins, which affects a variety of biologi...
