New role of PCSK9 in atherosclerotic inflammation promotion involving the TLR4/NF-κB pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tang, Zhi-Han;Peng, Juan;Ren, Zhong;Yang, Jing;Li, Ting-Ting;...

通讯作者：

Jiang, Zhi-Sheng

作者机构：

[Jiang, Zhi-Sheng; Ren, Zhong; Tang, Zhi-Han; Li, Tao-Hua; Wei, Dang-Heng; Peng, Juan; Li, Ting-Ting; Wang, Zuo; Liu, Lu-Shan] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Tang, Zhi-Han] Univ South China, Lab Expt Surg, Hengyang 421001, Hunan, Peoples R China.

[Yang, Jing] Univ South China, Lab Clin Res, Hengyang 421001, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta, Hlth Sci Ctr, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Jiang, Zhi-Sheng] U

Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

*Atherosclerosis;*Inflammation;*Macrophage;*PCSK9;*TLR4/ /NF-kappaB

期刊：

Ateroskleroz

ISSN：

2078-256X

年：

2017

卷：

262

页码：

113-122

DOI：

10.1016/j.atherosclerosis.2017.04.023

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [1200217, 81670429]; Educational Department of Hunan Province Fund for Distinguished Young Scholars [16B228]; Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (Chongqing University); Ministry of Education [CQKLBST-2015-004]; Construct Program of the Basic Medicine Key Discipline in Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Background and aims: Proprotein convertase subtilisin/kexin 9 (PCSK9) has emerged as a popular target in the development of new cholesterol-lowering drugs and therapeutic interventions for atherosclerosis. PCSK9 could accelerate atherosclerosis through mechanisms beyond the degradation of the hepatic lowdensity lipoprotein receptor. Several clinical studies suggested that PCSK9 is involved in atherosclerotic inflammation. Accordingly, this study aimed to explore the role of PCSK9 in vascular inflammation that promotes atherosclerotic progression. Methods: We examined whether PCSK9 silencing vi...

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New role of PCSK9 in atherosclerotic inflammation promotion involving the TLR4/NF-κB pathway

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