Performance of novel infection phase-dependent antigens in syphilis serodiagnosis and treatment efficacy determination

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成果类型：

期刊论文

作者：

Liu, Wen;Deng, Meixia;Zhang, Xiaohong;Yin, Weiguo;Zhao, Tie;...

通讯作者：

Zhao, Feijun

作者机构：

[Zhao, Feijun; Luo, Xi; Zhao, Tie; Liu, Wen; Zhang, Xiaohong; Zeng, Tiebing; Deng, Meixia] Univ South China, Pathogen Biol Inst, Hengyang Med Coll, Hengyang 421001, Peoples R China.

[Zhao, Feijun; Luo, Xi; Zhao, Tie; Liu, Wen; Zhang, Xiaohong; Zeng, Tiebing; Deng, Meixia] Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.

[Zhao, Feijun; Luo, Xi; Zhao, Tie; Liu, Wen; Zhang, Xiaohong; Zeng, Tiebing; Deng, Meixia] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Zhang, Xiaohong] Univ South China, Hengyang Med Coll, Dept Histol & Embryol, Hengyang 421001, Peoples R China.

[Yin, Weiguo] Yuebei Peoples Hosp, Lab Dept, Shaoguan 5120264, Peoples R China.

通讯机构：

[Zhao, Feijun] U

Univ South China, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Infection phase-dependent antigen;Serodiagnosis;Treatment efficacy;Treponema pallidum

期刊：

Clinica Chimica Acta

ISSN：

0009-8981

年：

2019

卷：

488

页码：

13-19

DOI：

10.1016/j.cca.2018.10.017

基金类别：

This work was funded by the National Natural Science Foundation of China (No. 81373230 and 81301470), the Hunan Provincial Education Department Innovation Platform Project (17k080) and the Guangdong Provincial Science and Technology Department Foundation (No. 2014A020212036). This work was supported by the Preclinical Medicine Hunan Provincial Key Disciplines, the Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control (No. 2014-5), and the Hunan Provincial Cooperative Role of the funding source The funders played no role in the study design, data collection or analysis, the decision to publish, or manuscript preparation.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Objective: The objective of this study was to screen new antigens for syphilis serodiagnosis. Methods: First, we determined whether the Treponema pallidum proteins Tp0971, Tp0768 and Tp0462 were infection phase-dependent antigens by observing serum reactivity differences in New Zealand rabbits infected with activated or inactivated T. pallidum. A non-infection phase-dependent antigen, the Tp92 membrane protein, was used as the negative control. Next, Tp0971-, Tp0768- and Tp0462-based ELISA was performed on 2138 human serum samples and compared ...

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Performance of novel infection phase-dependent antigens in syphilis serodiagnosis and treatment efficacy determination

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