Novel Self-Powered Biosensor Based on Highly Efficient Cosignal Accelerator and Multiple Signal Amplification Strategies toward Ultrasensitive miRNA-141 Assay

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Shen, Yan;Wang, Futing;Li, Yujin;Li, Jingxian;Lyu, Yifan;...

通讯作者：

Cai, R;Yang, HF

作者机构：

[Li, Jingxian; Lyu, Yifan; Shen, Yan; Li, Yujin; Wang, Futing; Cai, Ren; Tan, Weihong] Hunan Univ, Mol Sci & Biomed Lab, State Key Lab Chemo Biosensing & Chemometr, Coll Mat Sci & Engn,Coll Chem & Chem Engn,Coll Bio, Changsha 410082, Peoples R China.

[Li, Yujin] Xinyang Normal Univ, Coll Chem & Chem Engn, Xinyang 464000, Peoples R China.

[Yang, Dan] RMIT Univ, Sch Engn, Melbourne, Vic 3000, Australia.

[Yang, Hongfen] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

[Tan, Weihong] Chinese Acad Sci, Univ Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China.

通讯机构：

[Yang, HF ] U

[Cai, R ] H

Hunan Univ, Mol Sci & Biomed Lab, State Key Lab Chemo Biosensing & Chemometr, Coll Mat Sci & Engn,Coll Chem & Chem Engn,Coll Bio, Changsha 410082, Peoples R China.

Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

语种：

英文

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2025

卷：

期：

页码：

18227-18234

DOI：

10.1021/acs.analchem.5c03288

基金类别：

National Natural Science Foundation of China [22004032]; National Natural Science Foundation of China [2024JJ5348, 2021JJ20020]; Hunan Provincial Natural Science Foundation of China

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

A highly sensitive self-powered biosensor is designed based on gold-platinum nanorods (AuPt NRs) and the cascade reaction of catalytic hairpin assembly (CHA) and hybrid chain reaction (HCR) toward the miRNA-141 assay. As a cosignal accelerator, AuPt NRs enhance electrical conductivity between glucose oxidase (GOD) and a carbon paper (CP) electrode, thereby assisting in output signal enhancement. The cascade reaction of CHA-HCR is employed to efficiently amplify the detection signal and improve the sensitivity of the self-powered biosensor. Consequently, the self-powered biosensor provides high...

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Novel Self-Powered Biosensor Based on Highly Efficient Cosignal Accelerator and Multiple Signal Amplification Strategies toward Ultrasensitive miRNA-141 Assay

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