A Triple-Responsive and Dual-NIR Emissive Fluorescence Probe for Precise Cancer Imaging and Therapy by Activating Pyroptosis Pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Deng, Min;Wang, Peipei;Zhai, Zibo;Liu, Ying;Cheng, Dan;...

通讯作者：

He, Longwei;Li, SJ;He, LW

作者机构：

[Liu, Ying; Deng, Min; Zhai, Zibo; He, Longwei; Wang, Peipei; Li, Songjiao; Cheng, Dan; He, LW] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch, Dept Pharm & Pharmacol, Hengyang 421002, Peoples R China.

[Cheng, Dan] Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Hengyang Med Sch,Dept Gastroenterol, Hengyang 421002, Peoples R China.

[He, LW; He, Longwei] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China.

通讯机构：

[He, LW ] H

[Li, SJ ; He, LW] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch, Dept Pharm & Pharmacol, Hengyang 421002, Peoples R China.

Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China.

语种：

英文

关键词：

Chemotherapy;Fluorescence imaging;Theranostics;Cancer diagnosis;Cancer imaging;Cancer therapy;Fluorescence probes;Mitochondrias;Near Infrared;Near-infrared;Near-infrared channels;Theranostics;Tumor microenvironments;Mitochondria

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2025

卷：

期：

页码：

2998-3008

DOI：

10.1021/acs.analchem.4c06015

基金类别：

National Natural Science Foundation of China, NSFC, (22304074) National Natural Science Foundation of China, NSFC Natural Science Foundation of Hunan Province, (2022JJ30484, 2022JJ40358) Natural Science Foundation of Hunan Province Henan Normal University, HNU, (2024Y13) Henan Normal University, HNU

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Revealing changes in the tumor microenvironment is crucial for understanding cancer and developing sensitive methods for precise cancer imaging and diagnosis. Intracellular hydrogen peroxide (H(2)O(2)) and microenvironmental factors (e.g., viscosity and polarity) are closely linked to various physiological and pathological processes, making them potential biomarkers for cancer. However, a triple-response theranostic probe for precise tumor imaging and therapy has not yet been achieved due to the lack of effective tools. Herein, we present a mit...

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A Triple-Responsive and Dual-NIR Emissive Fluorescence Probe for Precise Cancer Imaging and Therapy by Activating Pyroptosis Pathway

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