The DNA-mediated growth strategy of bimetallic nanozymes is considered as an effective approach to regulate their peroxidase activity via tuning the morphology and nanostructure. Albeit important, its biosensing application in rational methods' design and performance improvement is limited due to the deficiency of a systematic understanding of the interactions between DNA and nanomaterials used. Herein, four homo-oligonucleotides as capping ligands were employed to functionalize the bimetallic nanozymes, where Pt nanoparticles (PtNPs) were in s...