gamma-Glutamyltransferase-Activatable Fluoro-Photoacoustic Reporter for Highly Sensitive Diagnosis of Acute Liver Injury and Tumor

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Qian;Yuan, Jie;Jiang, Renfeng;He, Longwei;Yang, Xuefeng;...

通讯作者：

Lin Yuan<&wdkj&>Dan Cheng

作者机构：

[Liu, Qian; Yang, Xuefeng; Cheng, Dan] Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Hengyang 421002, Hunan, Peoples R China.

[Yuan, Lin; Yuan, Jie; Cheng, Dan] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.

[Yuan, Jie] Henan Normal Univ, Sch Chem & Chem Engn, Henan Key Lab Green Chem Media & React, Key Lab Green Chem Media & React,Minist Educ, Xinxiang 453007, Peoples R China.

[He, Longwei; Jiang, Renfeng] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch, Dept Pharm & Pharmacol, Hengyang 421002, Hunan, Peoples R China.

通讯机构：

[Lin Yuan] S

[Dan Cheng] H

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China<&wdkj&>Hunan Provincial Clinical Research Center for Metabolic Associated Fatty Liver Disease, Clinical Research Institute, the Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, China<&wdkj&>State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China

语种：

英文

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2023

卷：

期：

页码：

2062-2070

DOI：

10.1021/acs.analchem.2c04894

基金类别：

National Natural Science Foundation of China [21904035, 21877029]; Science and Technology Project of Hunan Province [2021RC3108]; Hunan Provincial Natural Science Foundation of China [2022JJ10042, 2022JJ30484]; Special Funding for the Construction of Innovative Provinces in Hunan [2021SK4031]; China Postdoctoral Science Foundation [2020T130184]

机构署名：

本校为第一机构

院系归属：

医学院

药学与生物科学学院

摘要：

γ-Glutamyltransferase (GGT) has been recognized as an important clinical biomarker that is closely related to many diseases. Visualizing the GGT fluctuation facilitates early disease-related diagnosis and therapy. Herein, an activated probe (NIR-GGT) for the imaging of GGT activity was prepared. The probe consists of a stable NIR fluorophore with the tunable amino group decorated with the γ-glutamate group as a GGT-sensing unit linked by a self-elimination group. NIR-GGT can sensitively recognize GGT and cause a strong turn-on fluorescent and...

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gamma-Glutamyltransferase-Activatable Fluoro-Photoacoustic Reporter for Highly Sensitive Diagnosis of Acute Liver Injury and Tumor

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