Tumor Microenvironment-Responsive One-for-All Molecular-Engineered Nanoplatform Enables NIR-II Fluorescence Imaging-Guided Combinational Cancer Therapy

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成果类型：

期刊论文

作者：

Wu, Gui-long;Liu, Fen;Li, Na;Wang, Feirong;Yang, Sha;...

通讯作者：

Chen, Guodong;Tan, Xiaofeng;Yang, QL

作者机构：

[Xiao, Hao; Wu, Yinyin; Wu, Fan; Fu, Qian; Deng, Sanling; Li, Na; Li, Zelong; Liu, Fen; Tan, Xiaofeng; Wang, Minghui; Chen, Guodong; Kuang, Xin; Lin, Nanyun; Wang, Feirong; Yang, Qinglai; Sun, Lijuan; Kang, Qiang; Tan, XF; Wu, Gui-long; Wu, Peixian; Yang, Sha; Tan, Senyou] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg, Hengyang 421001, Hunan, Peoples R China.

[Xiao, Hao; Wu, Yinyin; Wu, Fan; Fu, Qian; Deng, Sanling; Li, Na; Li, Zelong; Liu, Fen; Tan, Xiaofeng; Wang, Minghui; Chen, Guodong; Kuang, Xin; Lin, Nanyun; Wang, Feirong; Yang, Qinglai; Sun, Lijuan; Kang, Qiang; Tan, XF; Wu, Gui-long; Wu, Peixian; Yang, Sha; Tan, Senyou] Univ South China, Canc Res Inst, Ctr Mol Imaging Probe, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Liu, Fen] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Radiol, Hengyang 421001, Peoples R China.

[Tan, Xiaofeng; Yang, Qinglai; Tan, XF] Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.

[Yang, Qinglai] Hunan Prov Maternal & Child Hlth Care Hosp, Key Lab Birth Defect Res & Prevent, Natl Hlth Commiss, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Tan, XF; Yang, QL ; Chen, GD] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Canc Res Inst, Ctr Mol Imaging Probe, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.

Hunan Prov Maternal & Child Hlth Care Hosp, Key Lab Birth Defect Res & Prevent, Natl Hlth Commiss, Changsha 410008, Hunan, Peoples R China.

语种：

英文

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2023

卷：

期：

页码：

17372-17383

DOI：

10.1021/acs.analchem.3c03827

基金类别：

the Natural Science Foundation of Hunan Province of China [22374065]; National Natural Science Foundation of China [2021RC3106]; Science and Technology Innovation Program of Hunan Province "Huxiang Young Talents Plan" [2022SK2053]; Key Research and Development Program of Hunan Province, China [2022JJ40360]; Natural Science Foundation of Hunan Province of China [22B0409]; Scientific Research Fund of Hunan Province Education Department [202209014713, 4310]; Scientific Research Project of the Hunan Provincial Health Commission of China [20214310NHYPY01]; University of South China [21A0258]; Scientific Research Key Project of Hunan Education Department [2021JJ70039]; Natural Science Foundation of Hunan Province (Joint Project of Science and Health) [20201064, 20201919]; Scientific Research Project of Health Commission of Hunan Province [2020SK51817]; Hunan Provincial Clinical Medical Technology Innovation Guide Project [20224310NHYCG01, 20214310NHYPY05]; University of South China Clinical Research 4310 Program; Medical Instrument and Equipment Technology Laboratory of Hengyang Medical College at the University of South China

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

The activable NIR-based phototheranostic nanoplatform (NP) is considered an efficient and reliable tumor treatment due to its strong targeting ability, flexible controllability, minimal side effects, and ideal therapeutic effect. This work describes the rational design of a second near-infrared (NIR-II) fluorescence imaging-guided organic phototheranostic NP (FTEP-TBFc NP). The molecular-engineered phototheranostic NP has a sensitive response to glutathione (GSH), generating hydrogen sulfide (H(2)S) gas, and delivering ferrocene molecules in the tumor microenvironment (TME). Under 808 nm irrad...

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Tumor Microenvironment-Responsive One-for-All Molecular-Engineered Nanoplatform Enables NIR-II Fluorescence Imaging-Guided Combinational Cancer Therapy

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