Self-Powered Biosensing System with Multivariate Signal Amplification for Real-Time Amplified Detection of PDGF-BB

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成果类型：

期刊论文

作者：

Wang, Futing;Wang, Peng;Yang, Hongfen;Cai, Ren;Tan, Weihong

通讯作者：

Cai, R;Yang, HF

作者机构：

[Wang, Futing; Cai, Ren; Tan, Weihong] Hunan Univ, Coll Mat Sci & Engn, Coll Chem & Chem Engn, Coll Biol,State Key Lab ChemoBio Sensing & Chemome, Changsha 410082, Peoples R China.

[Wang, Peng; Tan, Weihong] Univ Chinese Acad Sci, Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp,Hangzhou Inst Med, Hangzhou 310022, Zhejiang, Peoples R China.

[Tan, Weihong] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Shanghai 200127, Peoples R China.

[Tan, Weihong] Shanghai Jiao Tong Univ, Renji Hosp, Inst Mol Med, Coll Chem & Chem Engn, Shanghai 200127, Peoples R China.

[Yang, Hongfen; Yang, HF] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

通讯机构：

[Yang, HF ] U

[Cai, R ] H

Hunan Univ, Coll Mat Sci & Engn, Coll Chem & Chem Engn, Coll Biol,State Key Lab ChemoBio Sensing & Chemome, Changsha 410082, Peoples R China.

Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

语种：

英文

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2023

卷：

期：

页码：

16359-16365

DOI：

10.1021/acs.analchem.3c03662

基金类别：

National Natural Science Foundation of China [22004032]; Hunan Provincial Natural Science Foundation of China [2021JJ20020]

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

A self-powered biosensing system with multivariate signal amplification is designed for the ultrasensitive, highly efficient, rapid-response, and real-time detection of platelet-derived growth factor-BB (PDGF-BB). The biosensing system is composed of enzymatic biofuel cells (EBFCs), a capacitor, a digital multimeter (DMM), and a computer. Using the hybridization chain reaction (HCR), a few single DNA chains are transformed into abundant double-helix chains, which stimulates the reduction of [Ru(NH3)(6)](3+) to [Ru(NH3)(6)](2+) by electrostatic interaction, corresponding to the "on" state for H...

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Self-Powered Biosensing System with Multivariate Signal Amplification for Real-Time Amplified Detection of PDGF-BB

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