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Cysteine-Activatable Near-Infrared Fluorescent Probe for Dual-Channel Tracking Lipid Droplets and Mitochondria in Epilepsy

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成果类型:
期刊论文
作者:
Li, Songjiao;Wang, Peipei;Ye, Miantai;Yang, Ke;Cheng, Dan;...
通讯作者:
He, LW;Mao, ZQ
作者机构:
[Yang, Ke; He, Longwei; Wang, Peipei; Li, Songjiao; Cheng, Dan] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Dept Pharm & Pharmacol, Hengyang Med Sch, Hengyang 421002, Peoples R China.
[Ye, Miantai; Liu, Zhihong; Li, Songjiao] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China.
[Mao, Zhiqiang; Liu, Zhihong] Hubei Univ, Coll Hlth Sci & Engn, Wuhan 430062, Peoples R China.
通讯机构:
[He, LW ] U
[Mao, ZQ ] H
Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Dept Pharm & Pharmacol, Hengyang Med Sch, Hengyang 421002, Peoples R China.
Hubei Univ, Coll Hlth Sci & Engn, Wuhan 430062, Peoples R China.
语种:
英文
期刊:
Analytical Chemistry
ISSN:
0003-2700
年:
2023
卷:
95
期:
11
页码:
5133-5141
基金类别:
National Natural Science Foundation of China [22174034]; Natural Science Foundation of Hunan Province [2022JJ30484, 2022JJ10042, 2022JJ40358]; Start-up funds of University of South China [201RGC012, 220XQD030]; Research Foundation of Education Bureau of Hunan Province, China [22B0403]; Open Fund of State Key Laboratory of Chemo/Biosensing and Chemometrics [2021013, 2021015]
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Dual-channel fluorescent probes could respond to a specific target and emit different wavelengths of fluorescence before and after the response. Such probes could alleviate the influence caused by the variation of the probe concentration, excitation intensity, and so on. However, for most dual-channel fluorescent probes, the probe and fluorophore faced spectral overlap, which reduced sensitivity and accuracy. Herein, we introduced a cysteine (Cys)-responsive and near-infrared (NIR) emissive AIEgen (named TSQC) with good biocompatibility to dual...

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