Metal-organic frameworks (MOFs), which are self-assembled by metal ions and organic ligands through coordination chemistry, have periodically lattice crystalline porous structure, and have been widely used as materials due to their unique structures and properties. Because MOFs can greatly improve the target enrichment and signal enhancement performance of metal surface-enhanced Raman spectroscopy (SERS) substrates, MOFs- based SERS substrates have attracted much attention. The efficient SERS substrate enables SERS technology achieves high sensitivity, high selectivity, nondestructive and rapi...