This work was funded by the Hengyang City Science and Technology Planning Project [grant number 202150063473], the Scientific Research Project of Hunan Provincial Health Commission [grant number 202202044140], the Scientific Research Project of Hunan Provincial Education Department [grant number 21B0438], the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [grant number 2014-405], and Undergraduate Training Program for Innovation and Entrepreneurship of Hunan Prov-inceg[rant number2x02110555455].