Deacetylase-dependent and -independent role of HDAC3 in cardiomyopathy

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ren, Jieyu;Zeng, Qun;Wu, Hongmei;Liu, Xuewen;Guida, Maria C.;...

通讯作者：

Min Tang<&wdkj&>Min Tang Min Tang Min Tang

作者机构：

[Zeng, Qun; Li, Junjie; Wu, Hongmei; Liu, Xuewen; Tang, Min; Ren, Jieyu; Zhai, Yiyuan] Univ South China, Coll Hengyang Med, Dept Biochem & Mol Biol, Hengyang, Peoples R China.

[Ocorr, Karen; Guida, Maria C.; Bodmer, Rolf] Sanford Burnham Prebys Med Discovery Inst, Dev Aging & Regenerat Program, La Jolla, CA USA.

[Huang, Wen] Cent South Univ, Ctr Med Genet, Sch Life Sci, Changsha, Hunan, Peoples R China.

[Tang, Min] Univ South China, Changsheng West Rd 28,, Hengyang 421001, Peoples R China.

通讯机构：

[Min Tang; Min Tang Min Tang Min Tang] D

Department of Biochemistry and Molecular Biology, College of Hengyang Medical, University of South China, Hengyang, China

语种：

英文

关键词：

cardiac contractility;cardiomyopathy;deacetylase;Drosophila;fibrosis;Pericardin;triglycerides

期刊：

JOURNAL OF CELLULAR PHYSIOLOGY

ISSN：

0021-9541

年：

2023

卷：

238

期：

页码：

647-658

DOI：

10.1002/jcp.30957

机构署名：

本校为第一机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Cardiomyopathy is a common disease of cardiac muscle that negatively affects cardiac function. HDAC3 commonly functions as corepressor by removing acetyl moieties from histone tails. However, a deacetylase-independent role of HDAC3 has also been described. Cardiac deletion of HDAC3 causes reduced cardiac contractility accompanied by lipid accumulation, but the molecular function of HDAC3 in cardiomyopathy remains unknown. We have used powerful genetic tools in Drosophila to investigate the enzymatic and nonenzymatic roles of HDAC3 in cardiomyopathy. Using the Drosophila heart model, we showed ...

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Deacetylase-dependent and -independent role of HDAC3 in cardiomyopathy

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