Activation of Intestinal HIF2α Ameliorates Iron-Refractory Anemia

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成果类型：

期刊论文

作者：

Yu, Yingying;Su, Yunxing;Yang, Sisi;Liu, Yutong;Lin, Zhiting;...

通讯作者：

Min, Junxia;Wang, FD;Shah, YM

作者机构：

[Min, Junxia; Yu, Yingying; Wang, Fudi; Liu, Yutong; Zhou, Jiahui; Yue, Wuyang; Su, Yunxing; Yang, Sisi; Li, Xiaopeng; Min, JX; Sun, Shumin] Zhejiang Univ, Affiliated Hosp 1, Affiliated Hosp 2, Inst Translat Med,Sch Med, Hangzhou 310058, Peoples R China.

[Yu, Yingying; Wang, Fudi; Lin, Zhiting] Univ South China, Affiliated Hosp 1, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Shah, YM; Shah, Yatrik M.; Das, Nupur K.] Univ Michigan, Div Gastroenterol, Internal Med, Ann Arbor, MI 48109 USA.

[Shah, YM; Shah, Yatrik M.; Das, Nupur K.] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA.

[Wu, Qian] Zhejiang Univ, Int Inst Med, Sch Med, Yiwu, Zhejiang, Peoples R China.

通讯机构：

[Wang, FD ; Min, JX] Z

[Shah, YM ] U

Zhejiang Univ, Affiliated Hosp 1, Affiliated Hosp 2, Inst Translat Med,Sch Med, Hangzhou 310058, Peoples R China.

Univ South China, Affiliated Hosp 1, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Peoples R China.

Univ Michigan, Div Gastroenterol, Internal Med, Ann Arbor, MI 48109 USA.

语种：

英文

关键词：

anemia of inflammation;chemotherapy-induced anemia;FG-4592;HIF;hypoxia;iron-refractory iron deficiency anemia

期刊：

Advanced Science

ISSN：

2198-3844

年：

2024

卷：

期：

页码：

e2307022

DOI：

10.1002/advs.202307022

基金类别：

National Natural Science Foundation of China; China Postdoctoral Science Foundation [2022M712749, M642414]; National Institutes of Health [R01DK095201]; [31930057]; [32330047]; [31970689]; [32200964]; [32171166]; [82030003]; [32100941]; [32200961]

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

In clinics, hepcidin levels are elevated in various anemia-related conditions, particularly in iron-refractory anemia and in high inflammatory states that suppress iron absorption, which remains an urgent unmet medical need. To identify effective treatment options for various types of iron-refractory anemia, the potential effect of hypoxia and pharmacologically-mimetic drug FG-4592 (Roxadustat) are evaluated, a hypoxia-inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor, on mouse models of iron-refractory iron-deficiency anemia (IRIDA), anemia of inflammation and 5-fluorouracil-induced c...

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Activation of Intestinal HIF2α Ameliorates Iron-Refractory Anemia

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