Objective: To explore the application method and effect of objective structured clinical examination( OSCE) in the evaluation of clinical skills of nursing graduates in local colleges and universities. Methods: The OSCE assessment program was adopted to evaluate the clinical skills of 481 nursing graduates in local colleges and universities and the effect of assessment was analyzed. Results: The difficulty of OSCE examination program was moderate and the differentiation degree was higher,and it had good reliability and validity.Conclusion: OSCE can accurately an...