Chromobox homolog 8 (CBX8) Interacts with Y-Box binding protein 1 (YBX1) to promote cellular proliferation in hepatocellular carcinoma cells

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成果类型：

期刊论文

作者：

Xiao, Lushan;Zhou, Zixiao;Li, Wenwen;Peng, Jie;Sun, Qingcan;...

通讯作者：

Hou, Jin-Lin;Liu, Li

作者机构：

[Dong Zhongyi; Liu, Li; Li, Wenwen; Sun, Qingcan; Hou, Jin-Lin; Wu, Dehua; Song, Yang; Hou, JL; Liu, L; Xiao, Lushan; Cao, Hui-Chuan; Zhou, Zixiao; Sun, Jingyuan] Southern Med Univ, Nan Fang Hosp, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China.

[Liu, Li; Li, Wenwen; Sun, Qingcan; Hou, Jin-Lin; Song, Yang; Hou, JL; Liu, L; Xiao, Lushan; Zhou, Zixiao] Southern Med Univ, Nan Fang Hosp, Guangdong Prov Key Lab Viral Hepatitis Res, Guangzhou 510515, Guangdong, Peoples R China.

[Liu, Li; Li, Wenwen; Zhu, Hongbo; Sun, Qingcan; Hou, Jin-Lin; Song, Yang; Hou, JL; Liu, L; Xiao, Lushan; Zhou, Zixiao] Southern Med Univ, Nan Fang Hosp, Dept Infect Dis, Guangzhou 510515, Guangdong, Peoples R China.

[Dong Zhongyi; Wu, Dehua; Cao, Hui-Chuan; Sun, Jingyuan] Southern Med Univ, Nan Fang Hosp, Dept Radiat Oncol, Guangzhou 510515, Guangdong, Peoples R China.

[Peng, Jie] Guizhou Med Univ, Affiliated Hosp 2, Dept Oncol, Kaili, Peoples R China.

通讯机构：

[Hou, JL; Liu, L] S

Southern Med Univ, Nan Fang Hosp, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China.

Southern Med Univ, Nan Fang Hosp, Guangdong Prov Key Lab Viral Hepatitis Res, Guangzhou 510515, Guangdong, Peoples R China.

Southern Med Univ, Nan Fang Hosp, Dept Infect Dis, Guangzhou 510515, Guangdong, Peoples R China.

语种：

英文

关键词：

CBX8;HCC;HCC proliferation;YBX1;cyclin D1

期刊：

AGING-US

ISSN：

1945-4589

年：

2019

卷：

期：

页码：

7123-7149

DOI：

10.18632/aging.102241

基金类别：

National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81773008, 81672756, 81702390, 81872399, 81972897, 81802863]; Guangdong province Universities and Colleges Pearl River Scholar Funded Scheme (2015); Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2017A030310105, 2017A030311023, 2018030310285]; Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University [2017J003]; Guangzhou Technology Project [201804010044]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Polycomb group (PcG) proteins have recently been identified as critical regulators in tumor initiation and development. However, the function of CBX8 in human hepatocellular carcinoma (HCC) remains largely unknown. Our study was designed to explore the biological function and clinical implication of CBX8 in HCC. We investigated the interplay between CBX8 and cell cycle through Gene Set Enrichment Analysis and western blotting. Bioinformatics tools and co-immunoprecipitation were used to explore cell cycle regulation. Finally, we studied the expression and clinical significance of CBX8 in HCC t...

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Chromobox homolog 8 (CBX8) Interacts with Y-Box binding protein 1 (YBX1) to promote cellular proliferation in hepatocellular carcinoma cells

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