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Succinate accumulation induces pyroptosis and mitochondrial damage via the inhibition of ATP5F1D in HUVECs.

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成果类型:
期刊论文
作者:
Huang, Hong;Cui, Jian;Tang, Dan;Xiang, Xing;Mao, Jie;...
作者机构:
[He, Zhe; Tang, Huifang; Tang, Dan; Xiang, Xing; Hu, Hengjing; Cui, Jian; Mao, Jie; Huang, Hong] Hunan Provincial Key Laboratory of Multi-omics and Artificial Intelligence of Cardiovascular Diseases, University of South China, Hengyang 421001, China
[He, Zhe; Tang, Huifang; Tang, Dan; Xiang, Xing; Hu, Hengjing; Cui, Jian; Mao, Jie; Huang, Hong] Clinical Research Center for Myocardial Injury in Hunan Province, Hengyang 421001, China
[Tang, Huifang; Tang, Dan; Xiang, Xing; Cui, Jian; Mao, Jie; Huang, Hong] Institute of Cardiovascular Disease, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China
[Tang, Dan; Xiang, Xing] Department of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China
[Mao, Jie] School of Pharmaceutical Science, Hengyang Medical College, University of South China, Hengyang 421001, China
语种:
英文
关键词:
ATP5F1D;HUVEC pyroptosis;mitochondrial damage;succinate accumulation
期刊:
生物化学与生物物理学报(英文)
ISSN:
1672-9145
年:
2025
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
Atherosclerosis, a chronic inflammatory disorder, is pathophysiologically linked to endothelial cell (EC) pyroptosis. This study aims to elucidate the mechanisms by which succinate exacerbates EC pyroptosis through mitochondrial damage. Serum samples are collected from patients with coronary heart disease (CHD) and healthy controls (HCs), and the levels of succinate, interleukin (IL)-6, and IL-18 are quantified. To establish a succinate accumulation model, human umbilical vein endothelial cells (HUVECs) are treated with diethyl butyl malonate (DEBM), followed by analysis of inflammatory cytoki...

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