TMEM41B, a novel ER phospholipid scramblase mediating systemic lipid metabolism

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成果类型：

期刊论文

作者：

Hu Haoliang;Chen Zhe;Huang Shifang;Fu Chengxiao;Chen Linxi

通讯作者：

Fu, C.;Chen, L.

作者机构：

Changde Research Centre for Artificial Intelligence and Biomedicine, College of Life and Environmental Sciences, Hunan University of Arts and Science,,Institute of Pharmacy and Pharmacology, College of Basic Medical Science, Hengyang Medical School, Unive

Institute of Pharmacy and Pharmacology, College of Basic Medical Science, Hengyang Medical School, University of South China

Department of Pharmacology, Yongzhou Vocational Technical College

Institute of Pharmacy and Pharmacology, College of Basic Medical Science, Hengyang Medical School, University of South China,,The First Affiliated Hospital, Department of Pharmacy, Hengyang Medical School, University of South China

[Chen Linxi; Chen Zhe] Institute of Pharmacy and Pharmacology, College of Basic Medical Science, Hengyang Medical School, University of South China, Hengyang, 421200, China

通讯机构：

[Fu, C.; Chen, L.] I

Institute of Pharmacy and Pharmacology, China

语种：

英文

期刊：

生物化学与生物物理学报

ISSN：

1672-9145

年：

2022

卷：

期：

页码：

1761-1764

DOI：

10.3724/abbs.2022168

基金类别：

This work was supported by the grants from the National Natural Science Foundation of China (No. 81973326), the Natural Science Foundation of Hunan Province, China (Nos. 2022JJ40291 and 2021JJ80072), the Natural Science Foundation of Hunan Provincial Joint Fund for Science and Health (No. 2020JJ7068) and the Scientific Research Youth Foundation of Education Department of Hunan Province, China (No. 21B0610).

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

The phospholipid molecules forming the phospholipid bilayer membrane have difficulties to complete spontaneous trans-bilayer shuttling due to the physicochemical properties and biological functions of the membrane bilayer. However, this transbilayer phospholipid transport is essential in biology. Phospholipid synthesis is concentrated on the membrane of the endoplasmic reticulum (ER) of cells, which occurs only in the monolipid layer on the cytoplasmic side. Therefore, the formation of a complete bilayer membrane requires the phospholipids to be flipped to the other side. Transmembrane translo...

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TMEM41B, a novel ER phospholipid scramblase mediating systemic lipid metabolism

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