Curcumin ameliorates H_2O_2-induced injury through SIRT1-PERK-CHOP pathway in pancreatic beta cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cao, Zhaohui;Wu, Zhuan;Duan, Tingting;Tang, Cifei;Huang, Di;...

通讯作者：

Hu, X.

作者机构：

[Cao, Zhaohui; Hu, Xiaobo; Tang, Cifei; Duan, Tingting; Huang, Di; Wu, Zhuan] Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.

[Cao, Zhaohui; Hu, Xiaobo; Tang, Cifei; Duan, Tingting; Huang, Di; Wu, Zhuan] Univ South China, Hengyang Med Sch, Key Lab Ecol Environm & Crit Human Dis Prevent Hu, Hengyang 421001, Peoples R China.

[Wu, Zhuan] Guilin Med Univ, Affiliated Hosp 2, Cent Lab, Guangxi Hlth Commiss Key Lab Glucose & Lipid Meta, Guilin 541000, Peoples R China.

通讯机构：

[Hu, X.] D

Department of Biochemistry and Molecular Biology, Hengyang Medical School, University of South China, Hengyang, China

语种：

英文

关键词：

curcumin;ER stress;SIRT1;apoptosis

期刊：

生物化学与生物物理学报

ISSN：

1672-9145

年：

2022

卷：

期：

页码：

370-377

DOI：

10.3724/abbs.2022004

基金类别：

This work was supported by the grants from the Natural Science Fund of Hunan Province (No. 2021JJ30585), Hunan Provincial Department of Education Project (No. 21C0280), Education and Innovation Fund of University of South China (No. 2019JG029), and Graduate Research and Innovation Project of University of South China (No. 203YXC019).

机构署名：

本校为第一机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Oxidative stress and endoplasmic reticulum (ER) stress play crucial roles in pancreatic β cell destruction, leading to the development and progression of type 1 diabetes mellitus (T1DM). Curcumin, extracted from plant turmeric, possesses multiple bioactivities such as antioxidant, anti-inflammatory and anti-apoptosis properties in vitro and in vivo. However, it remains unknown whether curcumin improves ER stress to prevent β cells from apoptosis. In this study, we aim to investigate the role and mechanism of curcumin in ameliorating H2O2-indu...

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Curcumin ameliorates H_2O_2-induced injury through SIRT1-PERK-CHOP pathway in pancreatic beta cells

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