Endoplasmic reticulum(ER)is the largest organelle in eukaryotic cells, which can participate in the maintenance of calcium(Ca~(2+))homeostasis, protein synthesis and organelle communication[1]. Endoplasmic reticulum autophagy(ER-phagy)is a cellular quality control pathway mediated by autophagy receptors. ER-phagy involves the engulfing of excess or misfolded proteins and superfluous ER membrane to form autophagosomes which are degraded by lysosome[1]. ER-phagy occurs under normal conditions and is enhanced during starvation. At present, the receptors of ER-phagy in mammalian cells include fami...
