Mitochondrial metabolism in regulating macrophage polarization: an emerging regulator of metabolic inflammatory diseases

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成果类型：

期刊论文

作者：

Qing, Jina;Zhang, Zizhen;Novak, Petr;Zhao, Guojun*;Yin, Kai*

通讯作者：

Yin, Kai;Zhao, Guojun

作者机构：

[Yin, Kai; Novak, Petr; Qing, Jina] Guilin Med Univ, Affiliated Hosp 2, Guangxi Key Lab Diabet Syst Med, Guilin 541100, Peoples R China.

[Yin, Kai; Qing, Jina] Univ South China, Hengyang Med Coll, Res Lab Translat Med, Hengyang 421001, Peoples R China.

[Zhang, Zizhen] Hunan Polytech Environm & Biol, Sch Med, Hengyang 421001, Peoples R China.

[Zhao, Guojun] Guangzhou Med Univ, Gingyuan City Peoples Hosp, Affiliated Hosp 6, Gingyuan 511518, Peoples R China.

通讯机构：

[Yin, Kai; Zhao, Guojun] G

[Yin, Kai] U

Guilin Med Univ, Affiliated Hosp 2, Guangxi Key Lab Diabet Syst Med, Guilin 541100, Peoples R China.

Univ South China, Hengyang Med Coll, Res Lab Translat Med, Hengyang 421001, Peoples R China.

Guangzhou Med Univ, Gingyuan City Peoples Hosp, Affiliated Hosp 6, Gingyuan 511518, Peoples R China.

语种：

英文

关键词：

mitochondria;metabolism;inflammation;macrophage polarization

期刊：

生物化学与生物物理学报

ISSN：

1672-9145

年：

2020

卷：

期：

页码：

917-926

DOI：

10.1093/abbs/gmaa081

基金类别：

This work was supported by the grants from the National Natural Sciences Foundation of China (Nos. 81970390 and 81470569), the Natural Science Foundation of Hunan Province (No. 2018JJ2341), the Innovation Foundation for Postgraduate of Hunan Province (nos. CX2017B550 and CX2016B490), and the Foundation for Guangxi Key Laboratory of Diabetic Systems Medicine (No. 20-065-77).

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

As a major type of immune cells with heterogeneity and plasticity, macrophages are classically divided into inflammatory (M1) and alternative/anti-inflammatory (M2) types and play a crucial role in the progress of the inflammatory diseases. Recent studies have shown that metabolism is an important determinant of macrophage phenotype. Mitochondria, one of the most important compartments involving cell metabolism, are closely associated with the regulation of cell functions. In most types of cell, mitochondrial oxidative phosphorylation (OXPHOS) is the primary mode of cellular energy production....

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Mitochondrial metabolism in regulating macrophage polarization: an emerging regulator of metabolic inflammatory diseases

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